Gynostemma Extract

Catalog No.S2306

Gynostemma Extract is a saponins extract derived from the Gynostemma pentaphyllum.

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In DMSO USD 420 In stock
USD 320 In stock
USD 970 In stock
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Gynostemma Extract Chemical Structure

Gynostemma Extract Chemical Structure
Molecular Weight: 917.13

Validation & Quality Control

MSDS

Related Compound Libraries

Gynostemma Extract is available in the following compound libraries:

Product Information

Product Description

Biological Activity

Gynostemma Extract is a saponins extract derived from the Gynostemma pentaphyllum. The increase of SGOT, SGPT activities in CCl4 liver injury were significantly reduced by treatment with Gypenoside. It also elevated the A/G ratio. For the study of anti-fibrotic potential, Gypenoside reduced the collagen content by 33%. These phenomena were confirmed by pathologic observation; thinner bands of liver collagen were found. The results suggest that Gypenoside has hepatoprotective and anti-fibrotic activities.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesBaboonDogMonkeyRabbitGuinea pigRatHamsterMouse
Weight (kg)121031.80.40.150.080.02
Body Surface Area (m2)0.60.50.240.150.050.0250.020.007
Km factor202012128653
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)

Chemical Information

Download Gynostemma Extract SDF
Molecular Weight (MW) 917.13
Formula

C48H82O18

CAS No. 80321-63-7
Storage 3 years -20℃Powder
6 months-80℃in DMSO
Synonyms Gynostemma Pentaphyllum, Gypenoside
Solubility (25°C) * In vitro DMSO 189 mg/mL (206 mM)
Water <1 mg/mL (<1 mM)
Ethanol 189 mg/mL (206 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Research Area

Tech Support & FAQs

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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