Home Microbiology Anti-infection chemical Lauric Acid For research use only.

Lauric Acid

Synonyms: dodecanoic acid, N-Dodecanoic acid, Dodecylic acid

Lauric Acid (dodecanoic acid, N-Dodecanoic acid, Dodecylic acid) is a saturated medium-chain fatty acid with a 12-carbon backbone. Lauric acid is found naturally in various plant and animal fats and oils, and is a major component of coconut oil and palm kernel oil.

Lauric Acid Chemical Structure

Lauric Acid Chemical Structure

CAS: 143-07-7

Selleck's Lauric Acid has been cited by 1 publication

Purity & Quality Control

Batch: Purity: 99.57%
99.57

Lauric Acid Related Products

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Biological Activity

Description Lauric Acid (dodecanoic acid, N-Dodecanoic acid, Dodecylic acid) is a saturated medium-chain fatty acid with a 12-carbon backbone. Lauric acid is found naturally in various plant and animal fats and oils, and is a major component of coconut oil and palm kernel oil.
In vitro
In vitro Lauric acid induces apoptosis in Caco-2 (p<0.05) and IEC-6 cells (p<0.05). In Caco-2 cells, lauric acid reduces GSH availability and generated ROS compared to butyrate(p < 0.05). Lauric acid reduces Caco-2 and IEC-6 cells in G0/G1 and arrested cells in the S and G2/M phases. Lauric acid induces apoptosis in IEC-6 cells compared to butyrate(p < 0.05). Lauric acid induces high levels of ROS[1].
Cell Research Cell lines Caco-2 and IEC-6 cell lines
Concentrations 0.1, 0.3, 0.5 and 1 mM
Incubation Time 24, 48, 72, and 96 h
Method

Cell lines are harvested by enzymatic dissociation and seeded into 24-well tissue culture plates at 2.5 × 105 and 1.5 × 105 cells/ml, respectively. After 24 h of incubation, the medium is replaced with 1 ml of complete DMEM containing freshly prepared (50 mM )Lauric acid, conjugated to 0.4% FAF-BSA to final concentrations of 0.1, 0.3, 0.5 and 1 mM and compared to NaB (5 mM ) with 50 μl of 0.4% FAF-BSA as a vehicle control and incubated in a humidified atmosphere at 37℃ in 5% CO2 and, after enzymatic dissociation, assayed at 24, 48, 72, and 96 h. All experimental studies are undertaken in triplicate and measured in duplicate.

Chemical Information & Solubility

Molecular Weight 200.32 Formula

C12H24O2
CAS No. 143-07-7 SDF Download Lauric Acid SDF
Smiles CCCCCCCCCCCC(=O)O
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 40 mg/mL ( (199.68 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 40 mg/mL

Water : 20 mg/mL


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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