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| CCT137690 is a highly selective Aurora kinases inhibitor for Aurora-A, Aurora-B and Aurora-C with IC50 of 15 nM, 25 nM and 19 nM, respectively. | |
| CHIR 98014 is a potent and selective human GSK-3 inhibitor for human GSK-3ɑ and human GSK-3β with IC50 of 0.65 nM and 0.58 nM, respectively. | |
| AZ628 is a potent tyrosine protein inhibitor to wild-type CRAF and BRAF V600E with IC50 of 29 nM and 34 nM, respectively. | |
| AMG 458 is a potent inhibitor human c-Met or mouse c-Met with Ki of 1.2 nM or 2.0 nM. | |
| Anacetrapib is a potent and selective rhCETP and C13S CETP mutant inhibitor with IC50 of 7.9 nM and 11.8 nM, respectively. |
Recommended Products
| Olaparib (AZD2281) is a PARP inhibitor with IC50 of 5 and 1 nM for PARP-1 and PARP-2, respectively. | |
| BIBW2992 (Afatinib) is a next generation tyrosine kinase inhibitor (TKI) that irreversibly inhibits EGFR/HER2 kinase with an IC50 of 14 nM for in vitro potency against HER2. | |
| BEZ235 (NVP-BEZ235) is an inhibitor of PI3K and mTOR.p110, IC50<6nM. | |
| Cediranib (AZD2171) is a potent inhibitor of VEGF receptor tyrosine kinases. It inhibited VEGF-stimulated proliferation and KDR phosphorylation with IC50 of 0.4 and 0.5 nM, respectively. | |
| Perifosine is an Akt inhibitor. the antiproliferative properties of perifosine with an IC50 of 0.6–8.9 µM. | |
| AG-014699 (PF-01367338) is a PARP inhibitor (Ki, 1.4 nmol/L). | |
| MDV3100 is androgen-receptor antagonist inhibitor. Highly recommended inhibitor in AR research. | |
| AT9283 is a small molecule a multi-targeted c-ABL, JAK2, Aurora A and B inhibitor with of 4, 1.2, 1.1 and approximate 3 nM for Bcr-Abl(T3151), Jak2 and Jak3, aurora A and B, respectively. | |
| The primary target for Ponatinib (AP24534) is BCR-ABL, an abnormal tyrosine kinase inhibitor with IC50 of 0.37, 2, 1.5, 2.2, 1.1, 1 and 0.24 nM for native pan-BCR-ABL, mutated form, VEGFR2, FGFR1, PDGFRα, mutant FLT3 phosphorylation and LYN. | |
| AZD6244 (Selumetinib) also known as Selumetinib, ARRY142886, AZD-6244 & ARRY-142886 is MEK 1/2 inhibitor with GI50 values ranging from 14 to 50 nm. |
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