Selleckchem.com - Inhibitor Expert (Inhibitors, Compound Libraries)

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Inhibitor Expert (Inhibitors, Compound Libraries)

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Who are we?: Selleck Chemicals is one of the world leading suppliers of biochemical products and we commit ourselves to the highest products of signaling pathways such as MAPK and PI3K/Akt pathways, etc. We have over 1,000 products of inhibitors in addition to a variety of screening libraries.

Quality & Validation: Selleck Chemicals pays careful attention to the purity, stability, and activity evaluation of our products. Not only can we provide the chemical test data by NMR, LC-MS, and HPLC, but we can also provide detailed reviews from customers who have previously used our products. Western Blot, MTT, RT-PCR, and confocal microscopy images or figures provide a double guarantee for the biological activities of our products in life and biomedical science research. If you are in any way unsatisfied with the quality of our reagents, we will unconditionally refund or replace the product(s) in question.

Tech Support: Selleck Chemicals helps our customers use the products to their full potential. Our team is dedicated to customer satisfaction and you can expect helpful advice on all aspects of our products when you Contact Us.

Selleck-Pfizer Cooperation: Starting in 2013, Selleck Chemicals became a licensed supplier of Pfizer pharmaceuticals, granting our customers access to Pfizer’s exclusive and high quality compounds. Purchased individually or as a library, these compounds have a wide range of applications in preclinical research of human diseases. This newly forged partnership marks a major achievement for Selleck Chemicals. To continue growing as a company, we welcome and are seeking cooperative licensing with other major pharmaceutical companies.

Our Goal: Our goal is to provide scientists worldwide with easy access to the most innovative life science reagents in order to help them make significant discoveries in their respective fields.

Worldwide Relation & Overnight Delivery: Selleck Chemicals has established long-term and stable relationships with more than 10,000 customers from pharmaceutical and biotech companies to universities and research institutions. We have headquarters in the United States, Asia, Europe, and 38 distributors worldwide. We provide overnight delivery in North America and Europe.

In 2014, 2352 articles (32 with IF>20) cited Selleck products.More >

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IF of Sunitinib Malate (Sutent)

Figure | PDGFR-α regulates human β-cell EZH2 expression and proliferation. a, b, Representative images showing immunostaining for PDGFR-α (a), phospho-ERK1/2 (pERK1/2), phospho-RB-Ser 780 (pRB(Ser780)), EZH2 (b) and insulin (a and b) on pancreatic sections from juvenile and adult human subjects. PDGFR-α was detected in juvenile β-cells (arrows) but not in adult β-cells (arrowheads). Scale bars, 25 μm. c–f, Assessment of effects on human juvenile or adult islets after exposure to PDGF-AA (50 ng ml^-1) for 2 days, with or without Sunitinib (2 μM) or U0126 (10 μM)co-treatment. c, Islet EZH2 mRNAlevels after the indicated treatments.
IF of BEZ235 (NVP-BEZ235)

Three-dimensional responses of MCF7/IGF-1R cells to TAM (1 μM), E2 and IGF-1. Compared to parental MCF7 cells (a), MCF7/IGF-1R cells (b) in three-dimensional (3D) culture formed bigger acini in response to IGF-1 stimulation and displayed significant TAM resistance when treated with TAM (1 μM) + E2 + IGF-1, which was removable by kinase inhibitors BMS-536924, U0126 and BEZ235 (c). Cells (10,000/well) were seeded in 96-well plates. Acini were formed on 100% Matrigel and cultured for 14 days in starving medium containing 2% Matrigel and 5% charcoal/dextran-stripped fetal bovine serum with the treatments as indicated. Concentrations used: TAM (1 μM), E2 (1 nM) and IGF-1 (100 ng/mL). Confocal image original magnification, × 20. Red, rhodamine phalloidin (actin). Blue, Hoechst blue stain. Results are representative of two individual experiments.