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New Products

Cat.No. Product Name / Activity Added
S2727

PF299804

 Nov 2011
PF299804 is a potent, orally available, irreversible tyrosine kinase HER 1 (EGFR), HER2 and HER4 inhibitor with IC50 of 6, 45.7 and 73.7 nM for EGFR, ERBB2 and ERBB4, respectively.
S2696

GDC-0980 (RG7422)

 Nov 2011
GDC-0980 (RG7422) is a selective, dual PI3 Kinase and mTOR Kinase inhibitor with IC50 of 5, 27, 7, and 14 nM for PI3Kα, β, δ, and γ, respectively.
S2719

AMG 900

 Nov 2011
AMG 900 is a novel potent and highly selective Pan-aurora kinase inhibitor with an IC50 of median 3.5 nM.
S2720

ZM 336372

 Nov 2011
Zm 336372 is a potent, selective c-Raf inhibitor with an IC50 of 70 nM for inhibition of human c-Raf in vitro.
S2711

YO-01027

 Oct 2011
YO-01027 is a dipeptidic gamma-secretase inhibitor with IC50 of 2.6 and 2.9 nM for the proteolysis of APPL and Notch, respectively.
S2717

CP-91149

 Oct 2011
CP-91149 is a human liver glycogen phosphorylase α (HLGPα) inhibitor with an IC50 of 0.13 μM in the presence of 7.5 mM glucose.
S2703

GSK1838705A

 Oct 2011
GSK1838705A is a potent small-molecule IGF-IR, the insulin receptor and anaplastic lymphoma kinase (ALK) inhibitor with IC50 of 2.0, 1.6 and 0.5 nM, respectively.
S2677

BRL-15572

 Oct 2011
BRL-15572 is a hydrochloride salt form of BRL-15572 which is a selective serotonin receptor subtype 5-HT1D antagonist with an IC50 of 260 μM.
S2697

A-769662

 Oct 2011
A-769662 is a potent, reversible AMP-activated protein kinase (AMPK) activator with an EC50 of 0.8 μM.
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Arnaud AUTRET, Trinity College
"I would like to confirm you that everything is perfectly fine with ABT and Obatoclax we got from your company. We confirmed their activity in vitro. We notably observed their impact in an apoptotic model and results are similar to those which have been published."

Dongfeng Chen, The Rausing Lab
"Your product U0126(Cat.NO S1102) works well in our experiments. I hope I can get more excellent products from your company in future."

Dr. Alexandra Segref, CECAD Cologne,Germay
"I am very satisfied with your product and costumer service. Bortezomib works very well in our assay, it is comparably cheaper than other inhibitors that we tested is more reliable for our assays. We see a great effect by using 10nM concentration."

R.B. Cambridge
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Zhenghe John Wang Assistant Professor, Case Western Reserve University
"We have purchased LBH-589, Saha and MS-275 from you and they all worked well."

Jenny Sun
"We used the LBH-589 in our experiments. The compound is easy to use with excellent reproducibility."

Yu Wang, Harvard University
"The GDC0449 compound worked very well. The results in my hands are equally good as what's been published. Thanks for this great resource for our research."

Philip Seeman, Toronto University
"Your LY404039 compound was well synthesized, its complicated stereochemical structure confirmed by NMR spectroscopy, and was biologically excellent in acting on brain dopamine receptors."

Dung-Fang Lee
"Based on our preliminary data, I found MLN8237 and VX-680 have good effects in inhibiting Aurka-maintaining ESC self-renewal in mouse ES cells."

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