Home Microbiology Fungal inhibitor Patchouli alcohol For research use only.

Patchouli alcohol

Synonyms: (-)-Patchouli Alcohol, Patchoulol, Patchouli camphor

Patchouli alcohol (Patchoulol, Patchouli camphor), an ingredient in pogostemonis herba, has various pharmacological activities and acts as an inhibitor of asexual fungal propagation, inflammation, the influenza virus, and tumorigenesis.

Patchouli alcohol Chemical Structure

Patchouli alcohol Chemical Structure

CAS: 5986-55-0

Purity & Quality Control

Batch: S377801 DMSO] 44 mg/mL] false] ] ] false] ] ] false Purity: 98%
98

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Biological Activity

Description Patchouli alcohol (Patchoulol, Patchouli camphor), an ingredient in pogostemonis herba, has various pharmacological activities and acts as an inhibitor of asexual fungal propagation, inflammation, the influenza virus, and tumorigenesis.
In vitro
In vitro Patchouli alcohol inhibits the overexpression of iNOS and IL-6 in protein and mRNA levels in LPS-stimulated RAW264.7 and TNF-a stimulated HT-29 cells. Patchouli alcohol inhibits IkB-α degradation and p65 nuclear translocation, and subsequently suppresses transcriptional activity of NF-kB in LPS-stimulated RAW264.7 and TNF-α-stimulated HT-29 cells. In addition, Patchouli alcohol inhibits LPS- or TNF-α-stimulated ERK1/2 activation by decreasing phosphorylation of ERK1/2[1].
Cell Research Cell lines RAW264.7 and HT-29 cells
Concentrations 50 and 75 μM
Incubation Time 21 h
Method RAW264.7 and HT-29 cells (2×105 cells/well) are seeded in 12-well plates and incubated overnight. Then, plasmid mixtures containing 0.5 μg of pNF-kB-Luc plasmid and 0.1 μg of pRL-null vector are transfected for 24 h (for RAW264.7) and 48 h (for HT-29). The empty pGL3-basic vector is used as a negative control. After transfection, cells are pre-treated with Patchouli alcohol, tolfenamic acid (TA), or sulindac sulfide (SS) for 6 h and then co-treated with LPS (for RAW264.7) or TNF-α (for HT-29) for an additional 15 h. The cells are harvested in 1×luciferase lysis buffer, and luciferase activity is measured and normalized to the pRL-null luciferase activity using a dual-luciferase assay kit.

Chemical Information & Solubility

Molecular Weight 222.37 Formula

C15H26O
CAS No. 5986-55-0 SDF Download Patchouli alcohol SDF
Smiles CC1CCC2(C(C3CCC2(C1C3)C)(C)C)O
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 44 mg/mL ( (197.86 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


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