Magnolol

Synonyms: NSC 293099

Magnolol (NSC 293099) is a bioactive lignin found in the bark of the Houpu magnolia (Magnolia officinalis) which shows antifungal properties. It can block TNF-α-induced NF-κB activation.

Magnolol Chemical Structure

Magnolol Chemical Structure

CAS: 528-43-8

Selleck's Magnolol has been cited by 7 Publications

1 Customer Review

Purity & Quality Control

Batch: Purity: 99.95%
99.95

Magnolol Related Products

Signaling Pathway

Choose Selective NF-κB Inhibitors

Biological Activity

Description Magnolol (NSC 293099) is a bioactive lignin found in the bark of the Houpu magnolia (Magnolia officinalis) which shows antifungal properties. It can block TNF-α-induced NF-κB activation.
Targets
NF-κB [4]
In vitro
In vitro

Magnolol is a bioactive lignin found in the bark of the Houpu magnolia (Magnolia officinalis) which shows antifungal properties. Magnolol preferentially increases (3)H-muscimol binding to hippocampus compared to cortex and cerebellum in vitro. Magnolol has a more potent enhancing effect on GABAA receptor alpha2 subunit. [1] Magnolol shows significant inhibitory activities against Trichophyton mentagrophytes, Microsporium gypseum, Epidermophyton floccosum, Aspergillus niger, Cryptococcus neoformans, and Candida albicans with minimum inhibitory concentrations (MIC) in a range of 25-100 μg/ml. [2]

In Vivo
In vivo

LD50: Mice 2200mg/kg (i.g.). [3]

Chemical Information & Solubility

Molecular Weight 266.33 Formula

C18H18O2

CAS No. 528-43-8 SDF Download Magnolol SDF
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 53 mg/mL ( (199.0 mM); Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 53 mg/mL

Water : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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