Shikimic Acid

Catalog No.S2356

Shikimic acid(Shikimate), more commonly known as its anionic form shikimate, is an important biochemical intermediate in plants and microorganisms.

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Shikimic Acid Chemical Structure

Shikimic Acid Chemical Structure
Molecular Weight: 174.15

Validation & Quality Control

Quality Control & MSDS

Product Information

Product Description

Biological Activity

Description Shikimic acid(Shikimate), more commonly known as its anionic form shikimate, is an important biochemical intermediate in plants and microorganisms.
LD50
In vitro Shikimic acid (Shikimate), more commonly known as its anionic form shikimate, is an important biochemical intermediate in plants and microorganisms. Shikimic acid is a precursor for: the aromatic amino acids phenylalanine and tyrosine;indole, indole derivatives and aromatic amino acid tryptophan;many alkaloids and other aromatic metabolites;tannins, flavonoids, and lignin. [1]
In vivo
Features

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDogMonkeyBaboon
Weight (kg)0.020.151.80.40.0810312
Body Surface Area (m2)0.0070.0250.150.050.020.50.240.6
Km factor361285201220
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)
1

References

[1] Brown SA, et al. Nature, 1955, 175(4459), 688-689.

Chemical Information

Download Shikimic Acid SDF
Molecular Weight (MW) 174.15
Formula

C7H10O5

CAS No. 138-59-0
Storage 3 years -20℃powder
6 months-80℃in solvent
Synonyms Shikimate
Solubility (25°C) * In vitro DMSO 35 mg/mL (200.97 mM)
Water 35 mg/mL (200.97 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Name 1-Cyclohexene-1-carboxylic acid, 3,4,5-trihydroxy-, (3R,4S,5R)-

Tech Support & FAQs

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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