Home Immunology & Inflammation Immunology & Inflammation related chemical Sophoricoside For research use only.

Sophoricoside

Sophoricoside (SOPH) is an isoflavone isolated from Sophora japonica (Leguminosae) with numerous pharmacological effects, including anti- inflammatory, anti-cancer and immunosuppressive effects.

Sophoricoside Chemical Structure

Sophoricoside Chemical Structure

CAS: 152-95-4

Purity & Quality Control

Batch: S377601 DMSO] 86 mg/mL] false] Water] Insoluble] false] Ethanol] Insoluble] false Purity: 99.90%
99.90

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Biological Activity

Description Sophoricoside (SOPH) is an isoflavone isolated from Sophora japonica (Leguminosae) with numerous pharmacological effects, including anti- inflammatory, anti-cancer and immunosuppressive effects.
In vitro
In vitro Treatment with sophoricoside at concentrations of 1–10 μM inhibited lipid accumulation in HepG2 cells in a dose-dependent manner. At the same concentration range, no effect on cell viability was observed in the MTT assay. Inhibition of lipogenesis was associated with the downregulation of SREBP-1a, SREBP-1c, SREBP-2 and their downstream target genes (FAS, ACC, HMGR). Sophoricoside has the capability to increase glucose uptake by C2C12 myotubes. It also effectively inhibited the activities of α-glucosidase and α-amylase in vitro[1].
Cell Research Cell lines HepG2 Cells
Concentrations 0-75 μM
Incubation Time 48 h
Method

HepG2 cells were cultured in a 24-well plate. After reaching confluence, the cells were incubated for 48 h in the presence of sophoricoside. Subsequently, the culture medium was removed and replaced by 500 μL of fresh culture medium containing 10% sterile filtered MTT. After 3 h, the insoluble formazan crystals were dissolved in 500 μL/well isopropanol and absorbance was measured at 570 nm, using the 630 nm reading as a reference.
In Vivo
In vivo Sophoricoside remarkably lowered postprandial hyperglycaemia in starch-loaded C57BL6/J mice[1].
Animal Research Animal Models C57BL6/J mice
Dosages 50, 100 and 200 mg/kg
Administration oral

Chemical Information & Solubility

Molecular Weight 432.38 Formula

C21H20O10
CAS No. 152-95-4 SDF --
Smiles C1=CC(=CC=C1C2=COC3=CC(=CC(=C3C2=O)O)O)OC4C(C(C(C(O4)CO)O)O)O
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 86 mg/mL ( (198.89 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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