Research Area
Product Type
United States ( Change Country )
Dioscin (Collettiside III) Chemical Structure
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Biological Activity
Dioscin(Collettiside III) is extracted and isolated from Polygonatum Zanlanscianense Pamp with IC50 of 2.6, 0.8, 7.5, and 4.5 μM for the inhibition of the growth of the MDA-MB-435, H14, HL60, and HeLa cell lines, respectively. Hela cells underwent apoptosis in dose- and time-dependent manners when treated with Dioscin. Caspase-3, -8 and -9 activities were also detected. The low enzymatic activity of caspase-8 and high activity of caspase-9 showed that the mitochondrial pathway was activated in apoptosis. [1] [2]
Chemical Information
| Molecular Weight (WM): | 869.04 |
|---|---|
| Formula: | C45H72O16 |
| CAS No.: | 19057-60-4 |
| Synonyms: |
Collettiside III, CCRIS 4123
|
| Dissolve in (25°C): | DMSO ≥174mg/mL |
| Water <1mg/mL | |
| Ethanol ≥22mg/mL | |
| Storage: | 2 years-20°CPowder |
| 1 week-4°Cin DMSO | |
| 1 month-80°in DMSO |
Quality Control & MSDS
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