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Senkyunolide I
Synonyms: SEI, SENI
Senkyunolide I (SEI, SENI) is an orally active compound isolated from Ligusticum chuanxiong with analgesic, anti-migraine, neuroprotective, anti-oxidation and anti-apoptosis activities. Senkyunolide I (SEI, SENI) up-regulates the phosphorylation of Erk1/2 and induces Nrf2 nuclear translocation with enhanced HO-1 and NQO1 expressions. Senkyunolide I (SEI, SENI) promotes the ratio of Bcl-2/Bax and inhibits the expressions of cleaved caspase 3 and caspase 9.
Senkyunolide I Chemical Structure
CAS: 94596-28-8
Selleck's Senkyunolide I has been cited by 3 publications
Purity & Quality Control
Batch:
Purity:
99.89%
99.89
Senkyunolide I Related Products
| Related Targets | ERK1 ERK2 ERK5 ERK1/2 | Click to Expand |
|---|---|---|
| Related Compound Libraries | Kinase Inhibitor Library MAPK Inhibitor Library Cell Cycle compound library TGF-beta/Smad compound library Anti-alzheimer Disease Compound Library | Click to Expand |
Signaling Pathway
Choose Selective ERK Inhibitors
Biological Activity
| Description | Senkyunolide I (SEI, SENI) is an orally active compound isolated from Ligusticum chuanxiong with analgesic, anti-migraine, neuroprotective, anti-oxidation and anti-apoptosis activities. Senkyunolide I (SEI, SENI) up-regulates the phosphorylation of Erk1/2 and induces Nrf2 nuclear translocation with enhanced HO-1 and NQO1 expressions. Senkyunolide I (SEI, SENI) promotes the ratio of Bcl-2/Bax and inhibits the expressions of cleaved caspase 3 and caspase 9. | ||||||
|---|---|---|---|---|---|---|---|
| Targets |
|
| NCT Number | Recruitment | Conditions | Sponsor/Collaborators | Start Date | Phases |
|---|---|---|---|---|---|
| NCT05592483 | Recruiting | Breast Cancer |
AstraZeneca |
July 7 2023 | -- |
| NCT05013996 | Recruiting | Offense Sex |
University Hospital Tours |
January 20 2022 | Not Applicable |
| NCT05050045 | Completed | Pulmonary Hypertension of Newborn |
Marwa Mohamed Farag|Alexandria University |
August 1 2020 | -- |
Chemical Information & Solubility
| Molecular Weight | 224.25 | Formula | C12H16O4 |
| CAS No. | 94596-28-8 | SDF | -- |
| Smiles | CCC\C=C1/OC(=O)C2=C1CCC(O)C2O | ||
| Storage (From the date of receipt) | 3 years -20°C powder | ||
|
In vitro |
DMSO : 100 mg/mL ( (445.93 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.) Ethanol : 100 mg/mL Water : 33 mg/mL |
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In vivo Add solvents to the product individually and in order. |
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