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4-HNE (4-Hydroxynonenal)

Name: 4-HNE (4-Hydroxynonenal)
Brand: Selleck Chemicals
SKU: S9793
Rating: 5 (1 reviews)

Synonyms: HNE, 4-hydroxy Nonenal, 4-hydroxy-2-nonenal

Catalog No.S9793 Purity: 99.55%

4-HNE (4-Hydroxynonenal) is one of the major end products of lipid peroxidation and has been widely accepted as an inducer of oxidative stress.

4-HNE (4-Hydroxynonenal) Chemical Structure

CAS: 75899-68-2

Selleck's 4-HNE (4-Hydroxynonenal) has been cited by 1 publication

Purity & Quality Control

Batch: Purity: 99.55%

99.55

4-HNE (4-Hydroxynonenal) Related Products

Biological Activity

Description	4-HNE (4-Hydroxynonenal) is one of the major end products of lipid peroxidation and has been widely accepted as an inducer of oxidative stress.

In vitro
In vitro	4-Hydroxynonenal (4-HNE) is one of the main end products of lipid peroxidation, which induces the expression of heme oxygenase-1 (HO-1), peroxiredoxin-1 and stress protein A170 in an Nrf2-dependent manner in murine macrophages.<sup><a class="sref" href="#s_ref">[2]</a></sup>
Cell Research	Cell lines	Mouse Peritoneal Macrophages
	Concentrations	10 μM
	Incubation Time	24 h
	Method	Oil Red O Staining: Mouse peritoneal macrophages were incubated for 24 h at 37℃ in 5% CO2 in PRMI 1640 medium containing 10% FCS in the absence or presence of 4-Hydroxynonenal (4-HNE) (10 μM) or moxLDL or oxLDL (200 μg protein/ml). Cells were washed twice, fixed in formalin, and stained with oil red O. The area of lipid-loaded macrophages was measured using a computerized MacSCOPE image analysis system.

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-01-11)
NCT06126315	Not yet recruiting	Amyotrophic Lateral Sclerosis	Mario Negri Institute for Pharmacological Research\|University of Sydney\|FightMND	January 2024	Phase 2\|Phase 3
NCT05742698	Active not recruiting	Frontotemporal Dementia\|Frontotemporal Dementia Behavioral Variant\|Primary Progressive Aphasia\|bvFTD\|PPA\|FTD	Simon Ducharme MD\|Alzheimer''s Drug Discovery Foundation\|Douglas Mental Health University Institute	March 7 2023	Phase 2
NCT05829382	Active not recruiting	Healthy Aging	Helse Stavanger HF	March 15 2023	Not Applicable

References

Chemical Information & Solubility

Molecular Weight	156.22	Formula	C₉H₁₆O₂
CAS No.	75899-68-2	SDF	--
Density	0.9 g/mL
Storage (From the date of receipt)	2 years -20°C liquid	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	2 years -20°C liquid		1 month-20°Cin solvent

In vitro
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In vivo
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