Home DNA Damage/DNA Repair Topoisomerase inhibitor 9-amino-CPT (9-Aminocamptothecin) For research use only.

9-amino-CPT (9-Aminocamptothecin)

Synonyms: 9-AC, Aminocamptothecin, 9-amino-20(S)-camptothecin

9-amino-CPT (9-Aminocamptothecin, 9-AC, Aminocamptothecin, 9-amino-20(S)-camptothecin) is a Topoisomerase I inhibitor with potent anticancer activities. 9-amino-CPT (9-Aminocamptothecin) is an active, water-insoluble derivative of camptothecin.

9-amino-CPT (9-Aminocamptothecin) Chemical Structure

9-amino-CPT (9-Aminocamptothecin) Chemical Structure

CAS: 91421-43-1

Purity & Quality Control

Batch: S265301 4-Methylpyridine] 10 mg/mL] true] DMSO] 0.78 mg/mL] false] Water] Insoluble] false Purity: 99.17%
99.17

9-amino-CPT (9-Aminocamptothecin) Related Products

Signaling Pathway

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Biological Activity

Description 9-amino-CPT (9-Aminocamptothecin, 9-AC, Aminocamptothecin, 9-amino-20(S)-camptothecin) is a Topoisomerase I inhibitor with potent anticancer activities. 9-amino-CPT (9-Aminocamptothecin) is an active, water-insoluble derivative of camptothecin.
Targets
Topo I [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04909489 Unknown status
Traditional Chinese Medicine|Dyslipidemias|Syndrome
Dongzhimen Hospital Beijing
 April 21 2021 --
NCT03978624 Active not recruiting
Bladder Cancer
UNC Lineberger Comprehensive Cancer Center|Merck Sharp & Dohme LLC|Syndax Pharmaceuticals
 September 23 2020 Phase 2
NCT00003154 Completed
Lung Cancer
Case Comprehensive Cancer Center|National Cancer Institute (NCI)
 January 1998 Phase 2
NCT00002745 Completed
Lymphoma
National Cancer Institute (NCI)
 April 1996 Phase 2
NCT00251368 Completed
Leukemia Myelocytic Acute|Acute Lymphocytic Leukemia
Dana-Farber Cancer Institute|Brigham and Women''s Hospital|Beth Israel Deaconess Medical Center|Massachusetts General Hospital
 January 1995 Phase 1

Chemical Information & Solubility

Molecular Weight 363.37 Formula
C20H17N3O4
CAS No. 91421-43-1 SDF --
Smiles CCC1(C2=C(COC1=O)C(=O)N3CC4=CC5=C(C=CC=C5N=C4C3=C2)N)O
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

4-Methylpyridine : 10 mg/mL

DMSO : 0.78 mg/mL ( (2.14 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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