(-)-Epigallocatechin Gallate

Catalog No.S2250 Synonyms: EGCG

(-)-Epigallocatechin Gallate Chemical Structure

Molecular Weight(MW): 458.37

(-)-Epigallocatechin Gallate(EGCG) is the main catechin extraction of green tea that inhibits telomerase and DNA methyltransferase. EGCG blocks the activation of EGF receptors and HER-2 receptors. ECGG inhibits fatty acid synthase and glutamate dehydrogenase activity.

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In DMSO USD 160 In stock
USD 50 In stock
USD 70 In stock
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4 Customer Reviews

  • (a) Huh7 cells were incubated with HCVcc of JFH-1 for 2 h before overlaying with 1% agarose dissolved in culture medium or with AR3A anti-E2 neutralizing antibodies, in the presence of 20 μg/ml SZA. EGCG (50 μM) was introduced as a positive control. At 48 h post-infection, infected cells were quantified by IF. Nuclei were stained with DAPI. (b) Numbers of cells per positive colony were determined in 15 foci.

    Sci Rep, 2016, 6:27268.. (-)-Epigallocatechin Gallate purchased from Selleck.

    EGCG treatment increases cTnI protein levels in ageing hearts. (A) Western blotting analysis using cTnI and cTnT antibodies. b-Actin was used as protein loading control. (B) A summary of Western blotting results of cTnI. Values are expressed as mean S.D. from four separate experiments. Statistical significance was determined by ANOVA followed by least significant difference (LSD) tests. *P < 0.05 as compared with the 18M + EGCG and 3M groups. EGCG: epigallocatechin-3-gallate

    J Cell Mol Med, 2017. (-)-Epigallocatechin Gallate purchased from Selleck.

  • PLoS One 2013 8(8), e69519. (-)-Epigallocatechin Gallate purchased from Selleck.

    PLoS One 2013 8(8), e69519. (-)-Epigallocatechin Gallate purchased from Selleck.

Purity & Quality Control

Choose Selective Telomerase Inhibitors

Biological Activity

Description (-)-Epigallocatechin Gallate(EGCG) is the main catechin extraction of green tea that inhibits telomerase and DNA methyltransferase. EGCG blocks the activation of EGF receptors and HER-2 receptors. ECGG inhibits fatty acid synthase and glutamate dehydrogenase activity.
In vitro

(-)-Epigallocatechin gallate functions as a powerful antioxidant, preventing oxidative damage in healthy cells, but also as an antiangiogenic and antitumor agent and as a modulator of tumor cell response to chemotherapy. (-)-Epigallocatechin gallate shows multiple anticancer effects, such as anti-proliferation, anti-angiogenesis, transformation prevention of various cancer cells, cancer cell cycle arrest and inhibition of tumor metastasis. (-)-Epigallocatechin gallate exerts multi-anticancer effects through regulating several cancer-related cell signal pathways (regulated the function or the expression of key signal proteins, such as nuclear factor-κB, MAPKs and activator protein-1, EGFR, IGF, COX-2 signaling pathway, and so on.), effecting methylation of cancer genes and combination of ligand with membrane receptors. [1] (-)-Epigallocatechin gallate also shows an immunomodulating effects. Several types of immune cells in both the innate and adaptive immune systems are known to be affected in varying degrees by (-)-Epigallocatechin gallate. Among them, the dramatic effect on T cell functions has been repeatedly demonstrated, including T cell activation, proliferation, differentiation, and production of cytokines. Studies using animal models of autoimmune diseases have reported disease improvement in animals treated with green tea/EGCG. [2] (-)-Epigallocatechin gallate displays anti-infective properties. Antiviral activities of (-)-Epigallocatechin gallate with different modes of action have been demonstrated on diverse families of viruses, such as Retroviridae, Orthomyxoviridae and Flaviviridae and include important human pathogens like human immunodeficiency virus, influenza A virus and the hepatitis C virus. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
SH-SY5Y cells M1fofGZ2dmO2aX;uJIF{e2G7 MmLFUoV2em:ycn;0[YN1cW:wIHHnZYlve3RiYnX0ZU1idXmub3nkJJBmeHSrZHWgNU01Oi2rbnT1Z4VlKHSxeHnjbZR6KGmwIHj1cYFvKFOKLWPZOXkh[2WubIOgZZN{\XO|ZXSgZZMhdGGldHH0[UBl\Wi7ZILv[4Vv[XOnIILlcIVie2VuIFXDOVA:OC5yM{m4O{DPxE1? MljpNVkyOzh6NUm=
human MDA435/LCC6MDR cells MYXGeY5kfGmxbjDhd5NigQ>? NUfXcVBIOTBizszN MXO1JIRigXN? MkLFUY9lfWyjdHnvckBw\iCSLXfwJEh2dmuwb4fuJI9zcWerbjmgeJJidnOoZXP0[YQhcW5iaIXtZY4hVUSDNEO1M2xESz[PRGKgZ4VtdHNiYYPz[ZN{\WRiYYOgdoV3\XK|aXLs[UBw\iCyYXPsbZRigGWuIILld4l{fGGwY3WgcYVie3W{ZXSgZZMhUUN3MDDmc5IheGGlbHn0ZZhmdCCjdDCxNEB2VSCjZoTldkA2KGSjeYOgZpkhS2WubGTpeIVzKDl4IFHxeYVwfXNiYYPzZZktKEmFNUC9NE4yOjJ4IN88US=> M4rhWlI2QTh3MUm1
Sf9 cells M4jkUWZ2dmO2aX;uJIF{e2G7 M3nwTWlvcGmkaYTpc44hd2ZiSHnzOk11[WepZXSgbJVu[W5icnXjc41jcW6jboSgSG5OXDFiZYjwdoV{e2WmIHnuJIlve2WldDDT[lkh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwIFTORUBu\XSqeXz0doFve2[ncnHz[UBi[3Srdnn0fUB2e2mwZzC1K{1jcW:2aX75cIF1\WRiNEWtZpAhfW6vZYTofYxifGWmIH;yJIhmdWmvZYTofYxifGWmIH;sbYdwdnWlbHXveIll\SC|dXLzeJJifGW|IHHu[EBcO0ifLVHkc21mfCCkeTDsbZF2cWRic3PpcpRqdGyjdHnvckBkd3WwdHnu[{Bu\XSqb3SsJGlEPTB;MD61JO69VQ>? Ml:1NlU1ODZ7NES=
human U937 cells Ml:1SpVv[3Srb36gZZN{[Xl? MmfqTY5pcWKrdHnvckBw\iC2ZXzvcYVz[XOnIHnuJIh2dWGwIGW5N|ch[2WubIOsJGlEPTB;MTFOwG0> NVnLb3hoOjJ2MUO4OFU>
human HeLa cells M1jmdGZ2dmO2aX;uJIF{e2G7 NWSzdpRXUW6qaXLpeIlwdiCxZjD0[YxwdWW{YYPlJIlvKGi3bXHuJGhmVGFiY3XscJMhfXOrbnegOUcuSUGWIFPDS{BVS0diQVfDJGFISSCJVGStN{ch[XNic4Xid5Rz[XSnIHnuZ5Vj[XSnZDDmc5IhOTVibXnud{BxemmxcjD0c{BmgHSnboPpc44hemWjY4Tpc44h\m:ubH;3[YQh[nliY3;tdI92dmRid3HzbI92fCCkeTDzdIlvNXSnbH;t[ZJq[yC{ZYDlZZQh[W2ybHnmbYNifGmxbjDwdo91d2OxbDygTWM2OD1zLkC4JO69VQ>? MV:yNlQyOzh2NR?=
CHO cells M2r1eWN6fG:2b4jpZ:Kh[XO|YYm= NVzRWGNIPDhiaB?= NWjnR|BFS3m2b4TvfIlkcXS7IHHnZYlve3RiQ1jPJINmdGy|IHX4dJJme3OrbnegU2FVWDGEMzDoZZBtd3S7cHWgNUBi\nSncjC0PEBpenNiYomg[ox2d3Knc3PlcoNmKGKjc3XkJGNmdGyWaYTldk1IdG9iYYPzZZktKEmFNUC9N{4zKM7:TR?= MY[yN|MzPzh5Nx?=
MDCK cells M3z6emZ2dmO2aX;uJIF{e2G7 MoX6OEBl[Xm| M4r0UWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JIlv\my3ZX76ZUBCKH[rcoXzJEhCN3O5aX7lM29JNzVzMUS0OU8zODB5KFixUlEqMSCRaEegbY5n\WO2ZXSgbY4hVUSFSzDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKH[rcnHsJJJmeGyrY3H0bY9vKGGodHXyJFQh\GG7czDifUByfWGwdHn0ZZRqfmViUmStVGNTNCCHREWwQVgvOyEQvF2= M4PaWlIzOTF3NUmx
human HL60 cells MU\Qdo9tcW[ncnH0bY9vKGG|c3H5 MYOzJIRigXN? M4qwXWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iSFy2NEBk\WyuczDh[pRmeiB|IHThfZMtKEmFNUC9PU41KM7:TR?= MYOxPFY6OzB{MB?=
HSC-T6 cells  NEXXWVRHfW6ldHnvckBie3OjeR?= MV60PEBp MXjBcpRq\mmkcn;0bYMh[WO2aY\peJkh[WejaX7zeEBz[XRiSGPDMXQ3KGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[gdJJwdGmoZYLheIlwdiCjZoTldkA1QCCqcoOgZpkhSnKmVTDpcoNwenCxcnH0bY9vKGG|c3H5MEBKSzVyPUmuPUDPxE1? NYPHN4pnOjF3MES4OFg>
mouse 3T3-L1 cells M2OxeGZ2dmO2aX;uJIF{e2G7 NGPaUppKdmirYnn0bY9vKG:oIFe2VGQudWWmaXH0[YQhVkGGUFigdJJw\HWldHnvckBqdiCvb4Xz[UA{XDNvTEGgZ4VtdHNuIFnDOVA:OjVizszN M4Ll[FE5OzF|M{C4
mouse RAW264.7 cells MV3GeY5kfGmxbjDhd5NigQ>? Ml7ZOUBl[Xm| NFvqUm9KdmirYnn0bY9vKG:oIGLBUmtNNWmwZIXj[YQhd3O2ZX;jcIF{fG:pZX7ld4l{KGmwIH3veZNmKFKDV{K2OE44KGOnbHzzJIF{e2W|c3XkJIF{KGSnY4LlZZNmKGmwIGTSRXAueG:|aYTpeoUhdXWudHmtcpVkdGWjdHXkJINmdGy|IHHmeIVzKDViZHH5d{whUUN3ME2yPU45KM7:TR?= M1;KUVIyPDV4NUKx
HSC-T6 cells Ml;ZVJJwdGmoZYLheIlwdiCjc4PhfS=> M3S4XGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgdoF1KEiVQz3UOkBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5iY3XscEB3cWGkaXzpeJktKEmFNUC9NlkvQCEQvF2= NHrWNoszPTN{MkS1OS=>
human A431 cells MV3Qdo9tcW[ncnH0bY9vKGG|c3H5 MmXJOFghcA>? NH\Xd5RCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFG0N|Eh[2WubIOgc5ZmemW6cILld5NqdmdiRYLiRkBqdiC|ZYL1cU1nemWnIH3l[Il2dSCjc4Pld5Nm\CCjczDj[YxtKH[rYXLpcIl1gSCjZoTldkA1QCCqcoOgZpkhX1OWLUGgZZN{[XluIFXDOVA:OzhizszN NInQZWkzPDR3NkCwOC=>
human MDA-MB-231 cells MoTEVJJwdGmoZYLheIlwdiCjc4PhfS=> NXXxXlNbOjRiaB?= NUHSU5Y4SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNSGEuVUJvMkOxJINmdGy|IHHmeIVzKDJ2IHjyd{BjgSCPVGSgZZN{[Xl? M1LBfVIzPDV7MkC4
human HepG2 cells M1\4O2Z2dmO2aX;uJIF{e2G7 MXqyOEBp Mon4TY5pcWKrdHnvckBw\iCxbHXpZ{Bi[2mmLXnu[JVk\WRidILp[4x6[2W{aXTlJI93\XJvYXPjeY12dGG2aX;uJIlvKGi3bXHuJGhmeEd{IHPlcIx{KGmwY4XiZZRm\CCob4KgNlQhcHK|IILlcIF1cX[nIITvJJVvfHKnYYTl[EBkd262cn;s MoTsNlE5OjR4OUC=
human HepG2 cells MWLGeY5kfGmxbjDhd5NigQ>? MoPzNlQhcA>? NGfNeo9CdnSrb4jp[IFvfCCjY4Tpeol1gSCrbjDoeY1idiCKZYDHNkBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hd2Zib3zlbYMh[WOrZD3pcoR2[2WmIGLPV{Bo\W6ncnH0bY9vKGmwY4XiZZRm\CCob4KgNlQhcHK|IHL5JGRJS0ZvRFGgZoF{\WRiZnz1c5JqdWW2cnnjJIF{e2G7IILlcIF1cX[nIITvJJVvfHKnYYTl[EBkd262cn;s MWCyNVgzPDZ7MB?=
human Caco-2 cells MWnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? Mo\1NlUh|ryP NXm3VoFYPiCmYYnz MojPS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gR4Fkdy1{IHPlcIx{KGG2IEK1JJVOKGGodHXyJFYh\GG7cx?= M4jlNFE5OzJ2N{[z
mouse 3T3 cells M4LOVmZ2dmO2aX;uJIF{e2G7 M{XpTlEuOjBizszN Mk\rNVIhcA>? M33KU2FvfGmvaXfyZZRwenliYXP0bZZqfHliYXfhbY5{fCCVd3nzd{BidGKrbn:gcY92e2ViM2SzJINmdGy|IHHzd4V{e2WmIHHzJIlv[3KnYYPlJI9nKGOnbHygcpVu[mW{czDheEAyKHSxIEKwJJVOKGGodHXyJFEzKGi{czDifUBjgSC|Y4LheINpNXexdX7kJIF{e2G7 MYWyNVA5ODZ2Mh?=
human MDA-MB-231 cells MoHaVJJwdGmoZYLheIlwdiCjc4PhfS=> MYiyOEBp NX34OmpFSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNSGEuVUJvMkOxJINmdGy|IHHmeIVzKDJ2IHjyd{BjgSCPVGSgZZN{[Xl? NXfkT29MOjJ2NUmyNFg>
human Jurkat cells M165eWZ2dmO2aX;uJIF{e2G7 NF7jb3UyOC13NTFOwG0> M1LIflI1KGh? M3TPR2lvcGmkaYTpc44hd2ZiVF7GZYxxcGFvaX7keYNm\CCQRj3rZZBx[UJiYXP0bZZifGmxbjDpckBpfW2jbjDKeZJs[XRiY3XscJMh[XRiMUCgeI8hPTVidV2gZYZ1\XJiMkSgbJJ{KGK7IHXs[YN1em:yaH;y[ZRq[yCvb3LpcIl1gSC|aHnmeEBie3OjeR?= MVqyNVA5ODZ2Mh?=
human K562 cells NGXFeXVHfW6ldHnvckBie3OjeR?= NHfxXlYzPCCq MlHsTY5lfWO2aX;uJI9nKDZ5IHvEZUBt[W2rbnnuJJJm[2WydH;yJIV5eHKnc4Ppc44hcW5iaIXtZY4hUzV4MjDj[YxteyCjZoTldkAzPCCqcoOgZpkh\myxdzDjfZRwdWW2comgZY5idHm|aYO= NFjEeHozOTR|NE[wNy=>
human HL60 cells NETlOG9HfW6ldHnvckBie3OjeR?= MnrmNlQhcA>? M{XTcGlv\HWldHnvckBw\iB4NzDrSIEhdGGvaX7pckBz\WOncITvdkBmgHC{ZYPzbY9vKGmwIHj1cYFvKEiONkCgZ4VtdHNiYX\0[ZIhOjRiaILzJIJ6KG[ub4egZ5l1d22ndIL5JIFv[Wy7c3nz MWqyNVQ{PDZyMx?=
human Raji cells NUHtc4o6T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M4KxVlExKM7:TR?= M2iyb|Q5KGh? M1TGTWdzd3e2aDDpcohq[mm2aX;uJIFo[Wmwc4SgbJVu[W5iUnHqbUBk\WyuczDhd5Nme3OnZDDhd{Bk\WyuII\pZYJqdGm2eTDheEAyOCC3TTDh[pRmeiB2ODDodpMh[nlidIL5dIFvKGKudXWgZoF{\WRibXnjdo9{[2:yaXOgZY5idHm|aYOgbY4heHKnc3XuZ4Uhd2Zic4Xw[ZJwgGmmZTDkbZNufXSjc3W= M4m2NlIyPDN2NkCz
human PC3 cells MUPQdo9tcW[ncnH0bY9vKGG|c3H5 MmDPNVAuOTByIN88US=> MXO0PEBp MYTBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKFCFMzDj[YxteyCjdDCxNEB1dyBzMECgeW0h[W[2ZYKgOFghcHK|IHL5JIhmdW:leYTvcYV1emmlIHPlcIwh[2:3boTpcochdWW2aH;k M1\pU|I{QDZ5MU[3
human A431 cells M3X2U2Z2dmO2aX;uJIF{e2G7 NY[xdZZKOTByIN88US=> NVHzT4FZOTJiaB?= M1;GSHJm\HWldHnvckBw\iClbIXzeIVzcW6pIH;mJGdHWC2JUFmgbY4hdGmyaXSgdoFnfHNib3[gbJVu[W5iQUSzNUBk\WyuczDheEAyODBidV2gZYZ1\XJiMUKgbJJ{KGK7IHPvcoZw[2GuIH3pZ5Jwe2OxcHnjJIFv[Wy7c3nz M2Du[|I1PDV4MEC0
human SKBR3 cells MlTpSpVv[3Srb36gZZN{[Xl? NEK2VVMzODEQvF2= MWCzNEBucW6| NVuxV3c3TG:5boLl[5Vt[XSrb36gc4YhTXKkQkKgdJJwfGWrbjDlfJBz\XO|aX;uJIlvKGi3bXHuJHNMSlJ|IHPlcIx{KGmwIIPldpVuKG[{ZXWgcYVlcXWvIHH0JFIxOCC3TTDh[pRmeiB|MDDtbY5{KGK7IHntcZVvd2[udX;y[ZNk\W6lZTDzeIFqdmmwZz3iZZNm\CClb37mc4NidCCvaXPyc5Nkd3CrYzDhcoFtgXOrcx?= M3u0clI1PDV4MEC0
human 293T cells NU\NOYtzTnWwY4Tpc44h[XO|YYm= MUS1NEDPxE1? MXexNkBp M3fCOGlvcGmkaYTpc44hd2ZiRGnST|FCKGmwIHj1cYFvKDJ7M2SgZ4VtdHNiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJI9nKEeOSUGgeJJidnOlcnnweIlwdiCjY4Tpeol1gSCjdDC1NEB2VSCjZoTldkAyOiCqcoOgZpkh\HWjbD3seYNq\mW{YYPlJJJmeG:{dHXyJIdmdmViYYPzZZk> Mo\tNlIyPTR4NkS=

... Click to View More Cell Line Experimental Data

Protocol

Solubility (25°C)

In vitro Ethanol 83 mg/mL warmed (181.07 mM)
DMSO 72 mg/mL warmed (157.07 mM)
Water 23 mg/mL warmed (50.17 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 458.37
Formula

C22H18O11

CAS No. 989-51-5
Storage powder
Synonyms EGCG

Bio Calculators

Molarity Calculator

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

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Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02891538 Not yet recruiting Colon Cancer The University of Texas Health Science Center at San Antonio November 2016 --
NCT02832271 Not yet recruiting Endometriosis Chinese University of Hong Kong September 2016 Phase 2
NCT02577393 Enrolling by invitation Lung Neoplasms|Esophagitis|Prevention & Control|Epigallocatechin Gallate Shandong Cancer Hospital and Institute June 2015 Phase 2
NCT02731495 Completed Traumatic Brain Injury National Nutrition and Food Technology Institute|Tehran University of Medical Sciences March 2015 Phase 2|Phase 3
NCT02580279 Enrolling by invitation Breast Neoplasms|Dermatitis|Prevention & Control|Epigallocatechin Gallate Shandong Cancer Hospital and Institute February 2015 Phase 2
NCT02008721 Completed Multiple System Atrophy Dr. Johannes Levin|German Center for Neurodegenerative Diseases (DZNE)|Deutsche Parkinson Vereinigung|Deutsche Stiftung Neurologie|ParkinsonFonds Deutschland gGmbH|Ludwig-Maximilians - University of Munich January 2014 Phase 3

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Related Antibodies

Telomerase Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID