(-)-Epigallocatechin Gallate

Catalog No.S2250 Synonyms: EGCG

(-)-Epigallocatechin Gallate Chemical Structure

Molecular Weight(MW): 458.37

(-)-Epigallocatechin Gallate(EGCG) is the main catechin extraction of green tea that inhibits telomerase and DNA methyltransferase. EGCG blocks the activation of EGF receptors and HER-2 receptors. ECGG inhibits fatty acid synthase and glutamate dehydrogenase activity.

Size Price Stock Quantity  
In DMSO USD 160 In stock
USD 50 In stock
USD 70 In stock
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4 Customer Reviews

  • (a) Huh7 cells were incubated with HCVcc of JFH-1 for 2 h before overlaying with 1% agarose dissolved in culture medium or with AR3A anti-E2 neutralizing antibodies, in the presence of 20 μg/ml SZA. EGCG (50 μM) was introduced as a positive control. At 48 h post-infection, infected cells were quantified by IF. Nuclei were stained with DAPI. (b) Numbers of cells per positive colony were determined in 15 foci.

    Sci Rep, 2016, 6:27268.. (-)-Epigallocatechin Gallate purchased from Selleck.

    EGCG treatment increases cTnI protein levels in ageing hearts. (A) Western blotting analysis using cTnI and cTnT antibodies. b-Actin was used as protein loading control. (B) A summary of Western blotting results of cTnI. Values are expressed as mean S.D. from four separate experiments. Statistical significance was determined by ANOVA followed by least significant difference (LSD) tests. *P < 0.05 as compared with the 18M + EGCG and 3M groups. EGCG: epigallocatechin-3-gallate

    J Cell Mol Med, 2017. (-)-Epigallocatechin Gallate purchased from Selleck.

  • PLoS One 2013 8(8), e69519. (-)-Epigallocatechin Gallate purchased from Selleck.

    PLoS One 2013 8(8), e69519. (-)-Epigallocatechin Gallate purchased from Selleck.

Purity & Quality Control

Choose Selective Telomerase Inhibitors

Biological Activity

Description (-)-Epigallocatechin Gallate(EGCG) is the main catechin extraction of green tea that inhibits telomerase and DNA methyltransferase. EGCG blocks the activation of EGF receptors and HER-2 receptors. ECGG inhibits fatty acid synthase and glutamate dehydrogenase activity.
In vitro

(-)-Epigallocatechin gallate functions as a powerful antioxidant, preventing oxidative damage in healthy cells, but also as an antiangiogenic and antitumor agent and as a modulator of tumor cell response to chemotherapy. (-)-Epigallocatechin gallate shows multiple anticancer effects, such as anti-proliferation, anti-angiogenesis, transformation prevention of various cancer cells, cancer cell cycle arrest and inhibition of tumor metastasis. (-)-Epigallocatechin gallate exerts multi-anticancer effects through regulating several cancer-related cell signal pathways (regulated the function or the expression of key signal proteins, such as nuclear factor-κB, MAPKs and activator protein-1, EGFR, IGF, COX-2 signaling pathway, and so on.), effecting methylation of cancer genes and combination of ligand with membrane receptors. [1] (-)-Epigallocatechin gallate also shows an immunomodulating effects. Several types of immune cells in both the innate and adaptive immune systems are known to be affected in varying degrees by (-)-Epigallocatechin gallate. Among them, the dramatic effect on T cell functions has been repeatedly demonstrated, including T cell activation, proliferation, differentiation, and production of cytokines. Studies using animal models of autoimmune diseases have reported disease improvement in animals treated with green tea/EGCG. [2] (-)-Epigallocatechin gallate displays anti-infective properties. Antiviral activities of (-)-Epigallocatechin gallate with different modes of action have been demonstrated on diverse families of viruses, such as Retroviridae, Orthomyxoviridae and Flaviviridae and include important human pathogens like human immunodeficiency virus, influenza A virus and the hepatitis C virus. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
SH-SY5Y cells NYXMPWwxTnWwY4Tpc44h[XO|YYm= M3naOW5mfXKxcILveIVkfGmxbjDh[4FqdnO2IHLleIEu[W27bH;p[EBx\XC2aXTlJFEuPDJvaX7keYNm\CC2b4jpZ4l1gSCrbjDoeY1idiCVSD3TXVV[KGOnbHzzJIF{e2W|c3XkJIF{KGyjY4TheIUh\GWqeXTyc4dmdmG|ZTDy[Yxm[XOnLDDFR|UxRTBwMEO5PFch|ryP NGTjS4gyQTF|OEi1PS=>
human MDA435/LCC6MDR cells NUHkcI93TnWwY4Tpc44h[XO|YYm= MnPLNVAh|ryP Mle4OUBl[Xm| NFzGU5pOd2S3bHH0bY9vKG:oIGCt[5AhMHWwa37ve44hd3KrZ3nuLUB1emGwc3\lZ5Rm\CCrbjDoeY1idiCPRFG0N|UwVEOFNl3EVkBk\WyuczDhd5Nme3OnZDDhd{Bz\X[ncoPpZoxmKG:oIIDhZ4xqfGG6ZXygdoV{cXO2YX7j[UBu\WG|dYLl[EBieyCLQ{WwJIZweiCyYXPsbZRigGWuIHH0JFExKHWPIHHmeIVzKDViZHH5d{BjgSCFZXzsWIl1\XJiOU[gRZF2\W:3czDhd5NigSxiSVO1NF0xNjF{Mk[g{txO MmjzNlU6QDVzOUW=
Sf9 cells MWPGeY5kfGmxbjDhd5NigQ>? MnLJTY5pcWKrdHnvckBw\iCKaYO2MZRi\2enZDDoeY1idiC{ZXPvcYJqdmGwdDDEUm1VOSCneIDy[ZN{\WRiaX6gbY5{\WO2IGPmPUBk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5iRF7BJI1mfGi7bITyZY5{\mW{YYPlJIFkfGm4aYT5JJV{cW6pIEWnMYJqd3SrbonsZZRm\CB2NT3idEB2dm2ndHj5cIF1\WRib4KgbIVucW2ndHj5cIF1\WRib3zp[49vfWOuZX;0bYRmKHO3YoP0doF1\XNiYX7kJHs{UF1vQXTvUYV1KGK7IHzpdZVq\CC|Y3nueIltdGG2aX;uJINwfW62aX7nJI1mfGixZDygTWM2OD1yLkWg{txO MVWyOVQxPjl2NB?=
human U937 cells NGL4UYJHfW6ldHnvckBie3OjeR?= MULJcohq[mm2aX;uJI9nKHSnbH;t[ZJie2ViaX6gbJVu[W5iVUmzO{Bk\WyuczygTWM2OD1zIN88US=> Mmq0NlI1OTN6NEW=
human HeLa cells NFPFbFVHfW6ldHnvckBie3OjeR?= M4DUbWlvcGmkaYTpc44hd2ZidHXsc41memG|ZTDpckBpfW2jbjDI[WxiKGOnbHzzJJV{cW6pIEWnMWFCXCCFQ1egWGNIKEGJQzDBS2EhT1SWLUOnJIF{KHO3YoP0doF1\SCrbnP1ZoF1\WRiZn;yJFE2KG2rboOgdJJqd3JidH:g[Zh1\W6|aX;uJJJm[WO2aX;uJIZwdGyxd3XkJIJ6KGOxbYDveY5lKHejc3jveZQh[nlic4Dpck11\WyxbXXybYMhemWyZXH0JIFueGyrZnnjZZRqd25icILveI9kd2xuIFnDOVA:OS5yODFOwG0> NIHNZYMzOjRzM{i0OS=>
CHO cells NV\CfFNZS3m2b4TvfIlkyqCjc4PhfS=> MmrXOFghcA>? MlzrR5l1d3SxeHnjbZR6KGGpYXnud5QhS0iRIHPlcIx{KGW6cILld5NqdmdiT1HUVFFDOyCqYYDsc5R6eGViMTDh[pRmeiB2ODDodpMh[nliZnz1c5Jme2OnbnPlJIJie2WmIFPlcIxVcXSncj3HcI8h[XO|YYmsJGlEPTB;Mz6yJO69VQ>? MVGyN|MzPzh5Nx?=
MDCK cells MUfGeY5kfGmxbjDhd5NigQ>? MmTiOEBl[Xm| M37mNWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JIlv\my3ZX76ZUBCKH[rcoXzJEhCN3O5aX7lM29JNzVzMUS0OU8zODB5KFixUlEqMSCRaEegbY5n\WO2ZXSgbY4hVUSFSzDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKH[rcnHsJJJmeGyrY3H0bY9vKGGodHXyJFQh\GG7czDifUByfWGwdHn0ZZRqfmViUmStVGNTNCCHREWwQVgvOyEQvF2= M3PMdFIzOTF3NUmx
human HL60 cells NHrRbotRem:uaX\ldoF1cW:wIHHzd4F6 MX6zJIRigXN? NH\LeGxCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjMOlAh[2WubIOgZYZ1\XJiMzDkZZl{NCCLQ{WwQVkvPCEQvF2= NH7UNVcyQDZ7M{CyNC=>
HSC-T6 cells  MnS3SpVv[3Srb36gZZN{[Xl? MkDLOFghcA>? MnHERY51cW[rYoLveIlkKGGldHn2bZR6KGGpYXnud5QhemG2IFjTR{1VPiClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJBzd2yrZnXyZZRqd25iYX\0[ZIhPDhiaILzJIJ6KEK{ZGWgbY5kd3Kyb4LheIlwdiCjc4PhfUwhUUN3ME25Mlkh|ryP M1XFc|IyPTB2OES4
mouse 3T3-L1 cells MVLGeY5kfGmxbjDhd5NigQ>? MorLTY5pcWKrdHnvckBw\iCJNmDEMY1m\GmjdHXkJG5CTFCKIIDyc4R2[3Srb36gbY4hdW:3c3WgN3Q{NUxzIHPlcIx{NCCLQ{WwQVI2KM7:TR?= NIH5RlMyQDNzM{OwPC=>
mouse RAW264.7 cells NF;hOWVHfW6ldHnvckBie3OjeR?= MV21JIRigXN? NXvGOWl4UW6qaXLpeIlwdiCxZjDSRW5MVC2rbnT1Z4VlKG:|dHXvZ4xie3SxZ3Xu[ZNqeyCrbjDtc5V{\SCUQWeyOlQvPyClZXzsd{Bie3Onc4Pl[EBieyCmZXPy[YF{\SCrbjDUVmFRNXCxc3n0bZZmKG23bITpMY52[2ynYYTl[EBk\WyuczDh[pRmeiB3IHThfZMtKEmFNUC9NlkvQCEQvF2= Mn\mNlE1PTZ3MkG=
HSC-T6 cells MoqzVJJwdGmoZYLheIlwdiCjc4PhfS=> NFnseJNCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JJJifCCKU1OtWFYh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwIHPlcIwhfmmjYnnsbZR6NCCLQ{WwQVI6NjhizszN NGDuV24zPTN{MkS1OS=>
human A431 cells M4TUN3Bzd2yrZnXyZZRqd25iYYPzZZk> NWP2XoNGPDhiaB?= M{TI[WFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iQUSzNUBk\WyuczDveoVz\XiycnXzd4lv\yCHcnLCJIlvKHOncoXtMYZz\WVibXXkbZVuKGG|c3Xzd4VlKGG|IHPlcIwhfmmjYnnsbZR6KGGodHXyJFQ5KGi{czDifUBYW1RvMTDhd5NigSxiRVO1NF0{QCEQvF2= M1ex[lI1PDV4MEC0
human MDA-MB-231 cells M13vNHBzd2yrZnXyZZRqd25iYYPzZZk> M4G1NVI1KGh? Mn3ERY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPRFGtUWIuOjNzIHPlcIx{KGGodHXyJFI1KGi{czDifUBOXFRiYYPzZZk> NHnnTIwzOjR3OUKwPC=>
human HepG2 cells NVfUd4xJTnWwY4Tpc44h[XO|YYm= M1f4ZVI1KGh? NWXGOmZ7UW6qaXLpeIlwdiCxZjDvcIVq[yCjY3nkMYlv\HWlZXSgeJJq\2y7Y3XybYRmKG:4ZYKtZYNkfW23bHH0bY9vKGmwIHj1cYFvKEincFeyJINmdGy|IHnuZ5Vj[XSnZDDmc5IhOjRiaILzJJJmdGG2aY\lJJRwKHWwdILlZZRm\CClb370do9t NILTXWIzOTh{NE[5NC=>
human HepG2 cells MmXFSpVv[3Srb36gZZN{[Xl? NVXl[JdQOjRiaB?= NXvaPXluSW62aX;4bYRidnRiYXP0bZZqfHliaX6gbJVu[W5iSHXwS|Ih[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKG:oIH;s[YlkKGGlaXStbY5lfWOnZDDSU3Mh\2WwZYLheIlwdiCrbnP1ZoF1\WRiZn;yJFI1KGi{czDifUBFUEOILVTBJIJie2WmIH\seY9zcW2ndILpZ{Bie3OjeTDy[YxifGm4ZTD0c{B2dnS{ZXH0[YQh[2:wdILvcC=> MWSyNVgzPDZ7MB?=
human Caco-2 cells M{fl[2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NW[5V45ZOjVizszN NUnwZ5ZDPiCmYYnz M3P2eWdzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJGNi[29vMjDj[YxteyCjdDCyOUB2VSCjZoTldkA3KGSjeYO= Mk\uNVg{OjR5NkO=
mouse 3T3 cells MXTGeY5kfGmxbjDhd5NigQ>? MX:xMVIxKM7:TR?= NEP6dWwyOiCq MWTBcpRqdWmpcnH0c5J6KGGldHn2bZR6KGGpYXnud5QhW3erc4OgZYxjcW6xIH3veZNmKDOWMzDj[YxteyCjc4Pld5Nm\CCjczDpcoNz\WG|ZTDv[kBk\WyuIH71cYJmenNiYYSgNUB1dyB{MDD1UUBi\nSncjCxNkBpenNiYomgZpkhe2O{YYTjbE14d3WwZDDhd5NigQ>? NUn6ZY1JOjFyOEC2OFI>
human MDA-MB-231 cells NFvob3RRem:uaX\ldoF1cW:wIHHzd4F6 MVuyOEBp MnvZRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPRFGtUWIuOjNzIHPlcIx{KGGodHXyJFI1KGi{czDifUBOXFRiYYPzZZk> M{\UV|IzPDV7MkC4
human Jurkat cells NUL3OGpiTnWwY4Tpc44h[XO|YYm= NEjESGsyOC13NTFOwG0> Mn7tNlQhcA>? MmfWTY5pcWKrdHnvckBw\iCWTl\hcJBp[S2rbnT1Z4VlKE6ILXvhdJBiSiCjY4TpeoF1cW:wIHnuJIh2dWGwIFr1dotifCClZXzsd{BifCBzMDD0c{A2PSC3TTDh[pRmeiB{NDDodpMh[nliZXzlZ5Rzd3Cqb4LleIlkKG2xYnnsbZR6KHOqaX\0JIF{e2G7 M{PTb|IyODhyNkSy
human K562 cells MWfGeY5kfGmxbjDhd5NigQ>? NHe3RoczPCCq MU\JcoR2[3Srb36gc4YhPjdia1ThJIxidWmwaX6gdoVk\XC2b4Kg[ZhxemW|c3nvckBqdiCqdX3hckBMPTZ{IHPlcIx{KGGodHXyJFI1KGi{czDifUBndG:5IHP5eI9u\XS{eTDhcoFtgXOrcx?= NWjwcYl2OjF2M{S2NFM>
human HL60 cells M1XDW2Z2dmO2aX;uJIF{e2G7 MXqyOEBp NX\MU4VFUW6mdXP0bY9vKG:oIE[3JItF[SCuYX3pcolvKHKnY3XweI9zKGW6cILld5Nqd25iaX6gbJVu[W5iSFy2NEBk\WyuczDh[pRmeiB{NDDodpMh[nliZnzve{BkgXSxbXX0dpkh[W6jbInzbZM> NFjVbpUzOTR|NE[wNy=>
human Raji cells MojrS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M4WyW|ExKM7:TR?= MY[0PEBp M162W2dzd3e2aDDpcohq[mm2aX;uJIFo[Wmwc4SgbJVu[W5iUnHqbUBk\WyuczDhd5Nme3OnZDDhd{Bk\WyuII\pZYJqdGm2eTDheEAyOCC3TTDh[pRmeiB2ODDodpMh[nlidIL5dIFvKGKudXWgZoF{\WRibXnjdo9{[2:yaXOgZY5idHm|aYOgbY4heHKnc3XuZ4Uhd2Zic4Xw[ZJwgGmmZTDkbZNufXSjc3W= M3K0UFIyPDN2NkCz
human PC3 cells M2juVnBzd2yrZnXyZZRqd25iYYPzZZk> M2nm[FExNTFyMDFOwG0> M4fnTFQ5KGh? NXfOR3F3SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDQR|Mh[2WubIOgZZQhOTBidH:gNVAxKHWPIHHmeIVzKDR6IHjyd{BjgSCqZX3vZ5l1d22ndILpZ{Bk\WyuIHPveY51cW6pIH3leIhw\A>? MXKyN|g3PzF4Nx?=
human A431 cells M4nYT2Z2dmO2aX;uJIF{e2G7 MUOxNFAh|ryP NGry[2QyOiCq MoTMVoVlfWO2aX;uJI9nKGOudYP0[ZJqdmdib3[gS2ZRNUeSSTDpckBtcXCrZDDyZYZ1eyCxZjDoeY1idiCDNEOxJINmdGy|IHH0JFExOCC3TTDh[pRmeiBzMjDodpMh[nliY3;u[o9k[WxibXnjdo9{[2:yaXOgZY5idHm|aYO= MVqyOFQ2PjByNB?=
human SKBR3 cells MUnGeY5kfGmxbjDhd5NigQ>? M3[ze|IxOM7:TR?= MmrFN|AhdWmwcx?= NE[wTGZFd3ewcnXneYxifGmxbjDv[kBGemKEMjDwdo91\WmwIHX4dJJme3Orb36gbY4hcHWvYX6gV2tDWjNiY3XscJMhcW5ic3XyeY0h\nKnZTDt[YRqfW1iYYSgNlAxKHWPIHHmeIVzKDNyIH3pcpMh[nliaX3teY5w\my3b4Lld4NmdmOnIIP0ZYlvcW6pLXLhd4VlKGOxbn\vZ4FtKG2rY4Lvd4NweGmlIHHuZYx6e2m| M{HFeVI1PDV4MEC0
human 293T cells MmS1SpVv[3Srb36gZZN{[Xl? MYm1NEDPxE1? MX[xNkBp NH7vbVNKdmirYnn0bY9vKG:oIFTZVmsySSCrbjDoeY1idiB{OUPUJINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBw\iCJTFmxJJRz[W6|Y4LpdJRqd25iYXP0bZZqfHliYYSgOVAhfU1iYX\0[ZIhOTJiaILzJIJ6KGS3YXytcJVkcW[ncnHz[UBz\XCxcoTldkBo\W6nIHHzd4F6 NXnqNIxVOjJzNUS2OlQ>

... Click to View More Cell Line Experimental Data

Protocol

Solubility (25°C)

In vitro Ethanol 83 mg/mL warmed (181.07 mM)
DMSO 72 mg/mL warmed (157.07 mM)
Water 23 mg/mL warmed (50.17 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 458.37
Formula

C22H18O11

CAS No. 989-51-5
Storage powder
Synonyms EGCG

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

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    C4=C3/X C4: LOG(C4):
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Molecular Weight Calculator

Molecular Weight Calculator

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Definitions of molecular mass, molecular weight, molar mass and molar weight:

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Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02891538 Not yet recruiting Colon Cancer The University of Texas Health Science Center at San Antonio November 2016 --
NCT02832271 Not yet recruiting Endometriosis Chinese University of Hong Kong September 2016 Phase 2
NCT02577393 Enrolling by invitation Lung Neoplasms|Esophagitis|Prevention & Control|Epigallocatechin Gallate Shandong Cancer Hospital and Institute June 2015 Phase 2
NCT02731495 Completed Traumatic Brain Injury National Nutrition and Food Technology Institute|Tehran University of Medical Sciences March 2015 Phase 2|Phase 3
NCT02580279 Enrolling by invitation Breast Neoplasms|Dermatitis|Prevention & Control|Epigallocatechin Gallate Shandong Cancer Hospital and Institute February 2015 Phase 2
NCT02008721 Completed Multiple System Atrophy Dr. Johannes Levin|German Center for Neurodegenerative Diseases (DZNE)|Deutsche Parkinson Vereinigung|Deutsche Stiftung Neurologie|ParkinsonFonds Deutschland gGmbH|Ludwig-Maximilians - University of Munich January 2014 Phase 3

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Telomerase Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID