Catalog No.S2250 Synonyms: EGCG
Molecular Weight(MW): 458.37
(-)-Epigallocatechin Gallate(EGCG) is the main catechin extraction of green tea that inhibits telomerase and DNA methyltransferase. EGCG blocks the activation of EGF receptors and HER-2 receptors. ECGG inhibits fatty acid synthase and glutamate dehydrogenase activity.
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(a) Huh7 cells were incubated with HCVcc of JFH-1 for 2 h before overlaying with 1% agarose dissolved in culture medium or with AR3A anti-E2 neutralizing antibodies, in the presence of 20 μg/ml SZA. EGCG (50 μM) was introduced as a positive control. At 48 h post-infection, infected cells were quantified by IF. Nuclei were stained with DAPI. (b) Numbers of cells per positive colony were determined in 15 foci.
Sci Rep, 2016, 6:27268.. (-)-Epigallocatechin Gallate purchased from Selleck.
EGCG treatment increases cTnI protein levels in ageing hearts. (A) Western blotting analysis using cTnI and cTnT antibodies. b-Actin was used as protein loading control. (B) A summary of Western blotting results of cTnI. Values are expressed as mean S.D. from four separate experiments. Statistical significance was determined by ANOVA followed by least significant difference (LSD) tests. *P < 0.05 as compared with the 18M + EGCG and 3M groups. EGCG: epigallocatechin-3-gallate
J Cell Mol Med, 2017, 21(10):2481-2490. (-)-Epigallocatechin Gallate purchased from Selleck.
Purity & Quality Control
Choose Selective Telomerase Inhibitors
|Description||(-)-Epigallocatechin Gallate(EGCG) is the main catechin extraction of green tea that inhibits telomerase and DNA methyltransferase. EGCG blocks the activation of EGF receptors and HER-2 receptors. ECGG inhibits fatty acid synthase and glutamate dehydrogenase activity.|
(-)-Epigallocatechin gallate functions as a powerful antioxidant, preventing oxidative damage in healthy cells, but also as an antiangiogenic and antitumor agent and as a modulator of tumor cell response to chemotherapy. (-)-Epigallocatechin gallate shows multiple anticancer effects, such as anti-proliferation, anti-angiogenesis, transformation prevention of various cancer cells, cancer cell cycle arrest and inhibition of tumor metastasis. (-)-Epigallocatechin gallate exerts multi-anticancer effects through regulating several cancer-related cell signal pathways (regulated the function or the expression of key signal proteins, such as nuclear factor-κB, MAPKs and activator protein-1, EGFR, IGF, COX-2 signaling pathway, and so on.), effecting methylation of cancer genes and combination of ligand with membrane receptors.  (-)-Epigallocatechin gallate also shows an immunomodulating effects. Several types of immune cells in both the innate and adaptive immune systems are known to be affected in varying degrees by (-)-Epigallocatechin gallate. Among them, the dramatic effect on T cell functions has been repeatedly demonstrated, including T cell activation, proliferation, differentiation, and production of cytokines. Studies using animal models of autoimmune diseases have reported disease improvement in animals treated with green tea/EGCG.  (-)-Epigallocatechin gallate displays anti-infective properties. Antiviral activities of (-)-Epigallocatechin gallate with different modes of action have been demonstrated on diverse families of viruses, such as Retroviridae, Orthomyxoviridae and Flaviviridae and include important human pathogens like human immunodeficiency virus, influenza A virus and the hepatitis C virus. 
|In vitro||Ethanol||83 mg/mL warmed (181.07 mM)|
|DMSO||72 mg/mL warmed (157.07 mM)|
|Water||23 mg/mL warmed (50.17 mM)|
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Clinical Trial Information
|NCT Number||Recruitment||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT02891538||Not yet recruiting||Colon Cancer||The University of Texas Health Science Center at San Antonio||November 2016||--|
|NCT02832271||Not yet recruiting||Endometriosis||Chinese University of Hong Kong||September 2016||Phase 2|
|NCT02577393||Enrolling by invitation||Lung Neoplasms|Esophagitis|Prevention & Control|Epigallocatechin Gallate||Shandong Cancer Hospital and Institute||June 2015||Phase 2|
|NCT02731495||Completed||Traumatic Brain Injury||National Nutrition and Food Technology Institute|Tehran University of Medical Sciences||March 2015||Phase 2|Phase 3|
|NCT02580279||Enrolling by invitation||Breast Neoplasms|Dermatitis|Prevention & Control|Epigallocatechin Gallate||Shandong Cancer Hospital and Institute||February 2015||Phase 2|
|NCT02008721||Completed||Multiple System Atrophy||Dr. Johannes Levin|German Center for Neurodegenerative Diseases (DZNE)|Deutsche Parkinson Vereinigung|Deutsche Stiftung Neurologie|ParkinsonFonds Deutschland gGmbH|Ludwig-Maximilians - University of Munich||January 2014||Phase 3|
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