Hesperidin

Catalog No.S2309

Hesperidin is a flavanone glycoside found abundantly in citrus fruits.

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Hesperidin Chemical Structure

Hesperidin Chemical Structure
Molecular Weight: 610.56

Validation & Quality Control

Quality Control & MSDS

Product Information

Product Description

Biological Activity

Hesperidin is a flavanone glycoside found abundantly in citrus fruits. It is believed to play a role in plant defense. It acts as an antioxidant according to in vitro studies. [1] In human nutrition, it contributes to the integrity of the blood vessels. Various preliminary studies reveal novel pharmaceutical properties. It reduced cholesterol and blood pressure in rats. In a mouse study, large doses of the glucoside hesperidin decreased bone density loss. Another animal study showed protective effects against sepsis. Hesperidin has anti-inflammatory effects. It is also a potential sedative, possibly acting through opioid or adenosine receptors. [2][3]

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDog
Weight (kg)0.020.151.80.40.0810
Body Surface Area (m2)0.0070.0250.150.050.020.5
Km factor36128520
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)

Clinical Trial Information( data from http://clinicaltrials.gov, updated on 2016-05-07)

NCT Number Recruitment Conditions Sponsor
/Collaborators
Start Date Phases
NCT01773486 Withdrawn Obesity|Insulin Resistance University of Maryland June 2015 Phase 2
NCT02610491 Completed Metabolic Syndrome|Obesity Maastricht University Medical Center February 2015 Phase 2
NCT01477281 Not yet recruiting Chronic Venous Insufficiency|Disease Laboratório Teuto Brasileiro S/A February 2012 Phase 3
NCT01881204 Completed Osteoporosis, Postmenopausal Purdue University|Nestec Ltd. April 2011 --
NCT00914251 Recruiting Endothelial Dysfunction|Metabolic Syndrome University of Rome Tor Vergata November 2008 Phase 2

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Chemical Information

Download Hesperidin SDF
Molecular Weight (MW) 610.56
Formula

C28H34O15

CAS No. 520-26-3
Storage 3 years -20℃powder
6 months-80℃in solvent
Synonyms Cirantin
Solubility (25°C) * In vitro DMSO 122 mg/mL (199.81 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Name 4H-1-Benzopyran-4-one, 7-[[6-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-2,3-dihydro-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-, (2S)-

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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