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Methyl syringate TRP Channel agonist

Name: Methyl syringate
Brand: Selleck Chemicals
SKU: S4787
Availability: InStock
Rating: 5 (1 reviews)

Cat.No.S4787

Methyl syringate (Syringic Acid Methyl Ester), a plant phenolic compound, is a specific and selective TRPA1 agonist.

Chemical Structure

Molecular Weight: 212.20

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Quality Control

Batch: S478701 DMSO]42 mg/mL]false]]]false]]]false Purity: 99.96%

Cited in Nature Medicine for its top-tier quality
COA
SDS
Datasheet

99.96

Related Targets	CFTR CRM1 CD markers AChR Calcium Channel Sodium Channel Potassium Channel GABA Receptor ATPase GluR
Other TRP Channel Inhibitors	SKF96365 2-APB (2-Aminoethyl Diphenylborinate) AMG-517 GSK2193874 GSK1016790A HC-030031 Capsazepine EIPA (L593754) HC-067047 SB705498

Solubility

In vitro
Batch:

DMSO : 42 mg/mL (197.92 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	212.20	Formula	C₁₀H₁₂O₅	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	884-35-5	Download SDF		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	Syringic Acid Methyl Ester			Smiles	COC1=CC(=CC(=C1O)OC)C(=O)OC

Mechanism of Action

Targets/IC₅₀/Ki	TRPA1
In vitro	Methyl syringate increases cytosolic Ca2+ in human TRPA1 (hTRPA1)-transfected cells. This compound selectively activated hTRPA1 (EC(50) = 507.4 μM), but not hTRPV1.
In vivo	Methyl syringate regulates food intake and gastric emptying through a TRPA1-mediated pathway and, by extension, can contribute to weight suppression in ICR mice.
References	[1] https://pubmed.ncbi.nlm.nih.gov/23990963/ [2] https://pubmed.ncbi.nlm.nih.gov/23263817/ [3] https://pubmed.ncbi.nlm.nih.gov/26969386/

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