Curcumol

Catalog No.S2407

Curcumol Chemical Structure

Molecular Weight(MW): 236.35

Curcumol is a pure monomer isolated from Rhizoma Curcumaeis with antitumor activities.

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Biological Activity

Description Curcumol is a pure monomer isolated from Rhizoma Curcumaeis with antitumor activities.
Targets
JAK [2]
In vitro

Curcumol induced cell death in human lung adenocarcinoma (ASTC-a-1) cells by inducing G(2)/M phase arrest, nuclear fragmentation, phosphatidylserine externalization and a rapid translocation of Bax from cytosol into mitochondria. While, caspases are not involved in Curcumol-induced apoptosis. [1] Curcumol also benefits rheumatoid arthritis treatment through suppressing the fibroblast-like synoviocytes (FLS) proliferation and DNA synthesis. It attenuates PDGF-BB-induced Jak2 phosphorylation and downregulates STAT1 and STAT3 DNA-binding activities. [2]

Protocol

Solubility (25°C)

In vitro DMSO 47 mg/mL (198.85 mM)
Ethanol 47 mg/mL (198.85 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 236.35
Formula

C15H24O2

CAS No. 4871-97-0
Storage powder
Synonyms N/A

Bio Calculators

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00475683 Completed Chemotherapy Induced Mucositis Hadassah Medical Organization January 2009 Phase 3

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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JAK Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID