96 Well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode

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You can select compounds, quantities, format (dry/solid or DMSO), plate map, and concentration to meet your specific requirement.

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Product Description

Description & Advantages

    • A unique collection of 1163 FDA approved drugs for high throughput screening (HTS) and high content screening (HCS)
    • Locate new targets for old drugs
    • Bioactivity and safety confirmed by clinical trials
    • All compounds have been approved by FDA
    • Related to oncology, cardiology, anti-inflammatory, immunology, neuropsychiatry, analgesia etc
    • Structurally diverse, medicinally active, and cell permeable
    • Rich documentation with structure, IC50, and customer reviews
    • NMR and HPLC validated to ensure high purity

Product Details

Formulation: A collection of 1163 FDA approved drugs supplied as pre-dissolved DMSO solutions
Container: 96 Well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode
Stability:
3 months -20°C in DMSO
6 months -80°C in DMSO
Shipping: Blue ice
Packaging: Inert gas

FDA-approved Drug Library Contents

Download the FDA-approved Drug Library - SDF Download the FDA-approved Drug Library - XLSX

Contents are for reference only and are subject to change without notice.

Customer Reviews (5)

AS-605240 Review
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Rating
Source Cancer Cell,2011, 19, 1–13. Rapamycin (Sirolimus) purchased from Selleck
Method Cell viability Analysis
Cell Lines Ar+murine (CaP8) and human (LNCaP) prostate cancer cells, Pb-Cre+;PtenL/L mice, Pb-Cre+;PtenL/L;ArL/Y mice
Concentrations 1 nM, 4 mg/kg
Incubation Time 0-4 weeks
Results These data suggest that CaPs with AR loss have greater reliance upon the PI3K/AKT/mTOR-signaling pathways and that combined AR/androgen blockage in conjunction with PI3K/AKT/mTOR inhibition (by Rapamycin) is more effective for CaPs initiated by PTEN loss or PI3K/AKT activation.

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Rating
Source Dr Qi Long Lu of Carolinas Medical Center, Vorinostat (SAHA) purchased from Selleck
Method Hoechst staining
Cell Lines C2C12 cells
Concentrations
Incubation Time
Results

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Rating
Source Dr Mikhail Menshikov of Cardiology Research Center, Maraviroc purchased from Selleck
Method zymography
Cell Lines THP-1 cells
Concentrations 0-50 μM
Incubation Time 24 h
Results Analysis of receptor mechanisms mediating the induction of MMP-9 expression in THP-1 cells by AFP.

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Rating
Source Dr. Zhang of Tianjin Medical University, Temsirolimus (Torisel) purchased from Selleck
Method Western blotting
Cell Lines Breast cancer cells
Concentrations 0-5 nM
Incubation Time 24 h
Results Temsirolimus treatment resulted in a reduction of mTOR phosphorylation in Breast cancer cells.

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Rating
Source J Virol, 2011, 85, 2296–2303. Pazopanib HCl purchased from Selleck
Method Endothelial cell permeability assay
Cell Lines Endothelial cell
Concentrations 0-100 nM
Incubation Time 15-60 min
Results Figure A defines concentrations of kinase inhibitors which block ANDV-induced EC permeability approximately 50% (IC50s).The IC50s of pazopanib is 100 nM. we assessed the abilities of VEGFR2 and SFK inhibitors to block ANDV-induced permeability at their IC50s from 15 to 60 min after VEGF addition. The VEGFR2 kinase inhibitor pazopanib inhibited ANDV-induced permeability by 40 to 60% at nanomolar IC50 levels (Figure B).

Product Citations (20)

See Other Libraries

Tags: phosphatase inhibitor library