Myricetin

Catalog No.S2326 Synonyms: Cannabiscetin

Myricetin Chemical Structure

Molecular Weight(MW): 318.24

Myricetin, a natural flavonoid with antioxidant and anti tumor properties, is a novel inhibitor of MEK1 activity and transformation of JB6 P+ mouse epidermal cells. It also inhibits PI3Kγ with Kd of 0.17 μM.

Size Price Stock Quantity  
In DMSO USD 70 In stock
USD 50 In stock
USD 70 In stock
USD 120 In stock
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Biological Activity

Description Myricetin, a natural flavonoid with antioxidant and anti tumor properties, is a novel inhibitor of MEK1 activity and transformation of JB6 P+ mouse epidermal cells. It also inhibits PI3Kγ with Kd of 0.17 μM.
Targets
MEK1 [4] PI3Kγ [5]
0.17 μM(Kd)
In vitro

Myricetin(Cannabiscetin) is a flavonoid found in many grapes, berries, fruits, vegetables, herbs, as well as other plants, which has antioxidant and anti tumor properties. Myricetin has antioxidant properties. In vitro research suggests that myricetin in high concentrations can modify LDL cholesterol such that uptake by white blood cells is increased. [1] Studies shows that high myricetin consumption reduces the risk of prostate cancer and pancreatic cancer. [2] [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HT-29 cells M3nLO2Z2dmO2aX;uJIF{e2G7 MkfxSIV{\W6|aYTpfoF1cW:wIH;mJGdRWjN3IILlZ4VxfG:{IHnuJIh2dWGwIFjUMVI6KGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[gfoFxemmwYYP0MYlv\HWlZXSg[Jlv[W2rYzDtZZN{KHKnZHnzeJJq[nW2aX;uJIFnfGW{IEGwJI1qdnNuIFnDOVA:Oi5zMjFOwG0> M3TrdVI1QTByNES3
HeLa cells M1P4UWZ2dmO2aX;uJIF{e2G7 MWPJcohq[mm2aX;uJI9nKE2UUEGgeJJidnOoZXP0[YQhcW5iaIXtZY4hUGWOYTDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKFt|SG3MWGM1KHS{YX7zdI9zfCCkeTDyZZBq\CCoaXz0doF1cW:wIHHzd4F6NCCNaU2yMlQh|ryP NY\XOVZCOTl5MkW1O|g>
HCT116 cells M3L2ZWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NULHUoE2PDhiaB?= MoTnS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gTGNVOTF4IHPlcIx{KG:4ZYLlfJBz\XO|aX7nJHBKO0ujbIDoZUBJOTB2N2KgcZV1[W62IHHmeIVzKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVA:PC5zIN88US=> M{e5NlIzOjF{N{Kx
human 22Rv1 cells MVzQdo9tcW[ncnH0bY9vKGG|c3H5 NWfDXm95OTR2IHi= MoDtRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiB{MmL2NUBk\WyuczDpcoN2[mG2ZXSgeZAhfG9iMUS0JIhzeyCkeTDDc5VtfGW{IIDhdpRq[2ynIHPveY51KGGwZDDzbZpmKGGwYXz5foVzNCCLQ{WwQVE{NjFizszN NIfBUYwzOjd6OUixNi=>
human SKBR3 cells NUn4RW44TnWwY4Tpc44h[XO|YYm= NHmwdnQzPCCq M3z3b2Rqe3CuYXPlcYVvfCCxZjDHUU1kgTOEIH\yc40hUHOyOUCgbY4hcHWvYX6gV2tDWjNiY3XscJMh[W[2ZYKgNlQhcHK|IHL5JIZtfW:{ZYPj[Y5k\SCyb3zhdol7[XSrb36gZZN{[XluIFnDOVA:OTNwNTFOwG0> NHS1S|AzPDV2OEKwOy=>
human U2OS cells MUfGeY5kfGmxbjDhd5NigQ>? NYfCUYFpPSCq NYC3eIc4SWexbnnzeEBi[3Srdnn0fUBifCCJUGKzOUBz\WOncITvdkBqdiCqdX3hckBWOk:VIHPlcIx{KGOxZYjwdoV{e2mwZzDHZYw1NV[SMU[tWGVXKGG|c3Xzd4VlKGG|IHLleIEh[XK{ZYP0bY4hfHKjboPsc4NifGmxbjDh[pRmeiB3IHjyd{BjgSCkZYThJIxi[3SjbXHz[UBz\XCxcoTldkBo\W6nIHHzd4F6NCCHQ{WwQVE1NjdizszN MoDVNlQ6ODB2NEe=
human H9 cells Ml\SSpVv[3Srb36gZZN{[Xl? MUezJIRigXN? MkjnRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTGlXOSB|QjDpcoZm[3SnZDDpckBpfW2jbjDIPUBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oII\pdoFtKHKncHzpZ4F1cW:wIHHmeIVzKDNiZHH5d{BjgSCyMkSgZY51cWenbjDjZZB1fXKnIHHzd4F6NCCHQ{WwQVM2KM7:TR?= NVy2XWJ1QDF3OEG2OC=>
NCI-60 human tumor cell line MXnDfZRwfG:6aXPpeJkh[XO|YYm= Ml3GTY4hfmm2cn:gZ5l1d3SxeHnjJJBwfGWwY4mgZYdicW6|dDDOR2kuPjBiaIXtZY4hfHWvb4KgZ4VtdCCuaX7lMEBIUTVyPUO2JO69VQ>? MVO5OlMzOzZ4
human HL60 cells NVTlepdNWHKxbHnm[ZJifGmxbjDhd5NigQ>? M13HOVMxKM7:TR?= NW\RTYk1PDhiaB?= MUPBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEiONkCgZ4VtdHNiYYSgN|AhfU1iYX\0[ZIhPDhiaILzJIJ6KE2WUzDhd5NigQ>? MYKxPFI2QDR2MB?=
mouse L929 cells MULGeY5kfGmxbjDhd5NigQ>? MUKyJIg> NFjCdI9KdmirYnn0bY9vKG:oIILlZ49u[mmwYX70JIh2dWGwIGTOSk1idHCqYT3pcoR2[2WmIHP5eI91d3irY3n0fUBw\iCvb4Xz[UBNQTJ7IHPlcIx{KGG|c3Xzd4VlKGG|IIP1dpZqfmGuaYT5JJRz\WG2ZXSge4l1cCCmcoXnJIFnfGW{IEKgbJJ{KG:oIGTOSoFteGijIITy[YF1dWWwdB?= NGXMb2M6Ojh5NEG1

... Click to View More Cell Line Experimental Data

Protocol

Solubility (25°C)

In vitro DMSO 63 mg/mL (197.96 mM)
Ethanol 9 mg/mL warmed (28.28 mM)
Water Insoluble
In vivo Add solvents individually and in order:
4% DMSO+30% PEG 300+ddH2O
5mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 318.24
Formula

C15H10O8

CAS No. 529-44-2
Storage powder
Synonyms Cannabiscetin

Bio Calculators

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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MEK Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID