Dihydromyricetin

Catalog No.S2399 Synonyms: Ampeloptin

Dihydromyricetin Chemical Structure

Molecular Weight(MW): 320.25

Dihydromyricetin (Ampelopsin, Ampeloptin) is a natural antioxidant flavonoid from Ampelopsis grossedentata.

Size Price Stock Quantity  
In DMSO USD 220 In stock
USD 170 In stock
USD 320 In stock
USD 970 In stock

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2 Customer Reviews

  • A. Cal27 cells transfected with GFP-LC3 plasmid were treated with different concentration of DHM for 24 h. The formation of GFP-LC3 puncta were examined using immunofluorescence and quantified. Scale bar 50 μm.

    Oncotarget, 2016.. Dihydromyricetin purchased from Selleck.

    ADH and ALDH expressions in 40% ethanol loaded mice for three hours. Group 1, 500 lM taraxerone; Group 2, 1 mM taraxerone; Group 3, 3 mM DHM (positive control); Group 4, DMSO (control); Group 5, saline. Taraxerone and DHM were dissolved in DMSO, and all treated samples (ethanol, taraxerone, DHM, DMSO, and saline) were administered orally (5 mL/kg body weight). The same letters denote significant differences at p < 0.05, and the error bar represents standard deviation.

    Food Chem Toxicol 2012 50, 2508-2514. Dihydromyricetin purchased from Selleck.

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Biological Activity

Description Dihydromyricetin (Ampelopsin, Ampeloptin) is a natural antioxidant flavonoid from Ampelopsis grossedentata.
Targets
GABAA receptor [1] GABAA receptor [2]
In vitro

Dihydromyricetin shows antioxidant activity as an effective scavenger of 1,1-diphenyl-2-picrylhydrazyl radical (DPPH). It also inhibits the increase of lipid peroxidation (LPO) values in linolei acid system catalyzed by FeSO4-edetic acid. [1] DHM (1 μM) as a novel anti-alcohol intoxication medication antagonizes both acute EtOH-induced potentiation of GABA(A)Rs and EtOH exposure/withdrawal-induced GABA(A)R plasticity and increases in GABA(A)R alpha4 subunit expression in hippocampus and cultured neurons. [2]

In vivo Dihydromyricetin (1 mg/kg, i.p.) counteracts acute alcohol (EtOH) intoxication, and also withdrawals signs in rats including tolerance, increased anxiety, and seizure susceptibity. [2] LD50: Mice 1.41g/kg (i.p.) [3]

Protocol

Solubility (25°C)

In vitro DMSO 64 mg/mL (199.84 mM)
Ethanol 64 mg/mL (199.84 mM)
Water <1 mg/mL
In vivo

* 1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 320.25
Formula

C15H12O8

CAS No. 27200-12-0
Storage powder
in solvent
Synonyms Ampeloptin

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID