Dihydromyricetin

Dihydromyricetin (Ampelopsin, Ampeloptin) is a natural antioxidant flavonoid from Ampelopsis grossedentata.

Price Stock Quantity  
In DMSO USD 220 In stock
USD 170 In stock
USD 320 In stock
USD 970 In stock
USD 2470 In stock
Bulk Inquiry

Massive Discount Available

Free Overnight Delivery on all orders over $ 500.

Dihydromyricetin Chemical Structure

Dihydromyricetin Chemical Structure
Molecular Weight: 320.25

Validation & Quality Control

Customer Reviews(1)

Quality Control & MSDS

Related Compound Libraries

Dihydromyricetin is available in the following compound libraries:

Product Information

  • Compare Others
    Compare Others

Product Description

Biological Activity

Description Dihydromyricetin (Ampelopsin, Ampeloptin) is a natural antioxidant flavonoid from Ampelopsis grossedentata.
Targets
IC50
LD50
In vitro Dihydromyricetin shows antioxidant activity as an effective scavenger of 1,1-diphenyl-2-picrylhydrazyl radical (DPPH). It also inhibits the increase of lipid peroxidation (LPO) values in linolei acid system catalyzed by FeSO4-edetic acid. [1] DHM (1 μM) as a novel anti-alcohol intoxication medication antagonizes both acute EtOH-induced potentiation of GABA(A)Rs and EtOH exposure/withdrawal-induced GABA(A)R plasticity and increases in GABA(A)R alpha4 subunit expression in hippocampus and cultured neurons. [2]
In vivo Dihydromyricetin (1 mg/kg, i.p.) counteracts acute alcohol (EtOH) intoxication, and also withdrawals signs in rats including tolerance, increased anxiety, and seizure susceptibity. [2] LD50: Mice 1.41g/kg (i.p.) [3]
Features

Protocol(Only for Reference)

1

References

Chemical Information

Download Dihydromyricetin SDF
Molecular Weight (MW) 320.25
Formula

C15H12O8

CAS No. 27200-12-0
Storage 3 years -20℃Powder
6 months-80℃in DMSO
Syonnyms Ampeloptin, Ampelopsin,(+)-Ampelopsin, (+)-Dihydromyricetin
Solubility (25°C) * In vitro DMSO 64 mg/mL (199 mM)
Water <1 mg/mL (<1 mM)
Ethanol 64 mg/mL (199 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Name (2R,3R)-3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-2,3-dihydrochromen-4-one

Preparing Stock Solutions

Stock Solution (1ml DMSO) 1mM 10mM 20mM 30mM
Mass(mg) 0.32025 3.2025 6.405 9.6075

Research Area

Customer Reviews (1)


Click to enlarge
Rating
Source Food and Chemical Toxicology 50 (2012) 2508–2514. Dihydromyricetin purchased from Selleck
Method Enzymetic acitivity
Cell Lines mouse
Concentrations 3mM,5mL/Kg, Orally,
Incubation Time 3 hr
Results The DHM-treated groups also showed lower ethanol and acetaldehyde concentrations than that of the control group,however, 1 mM DHM did not affect the ADH and ALDH activities. The enhancing effects of taraxerone on ADH and ALDH activities were approximately 1.5 and 2 times higher than that of DHM at 3 and 5 mM treatments, respectively.

Product Citations (1)

Tech Support & FAQs

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

* Indicates a Required Field

Related Others

  • SRPIN340

    SRPIN340 is a selective SRPK inhibitor with Ki of 0.89 μM for SRPK1, showing no significant inhibitory activity against more than 140 other kinases..

    Features:The only specific SRPK1 and SRPK2 inhibitor. Potential use in congenital diseases and viral diseases including HIV, HCV and HBV.

  • RI-1

    RI-1 is a RAD51 inhibitor with IC50 ranging from 5 to 30 μM.

    Features:A selective recombinant RAD51 protein inhibitor discovered in 2012. Valuable tool for mechanistic studies of DNA repair and potential for use in many cancers.

  • OAC1

    OAC1 (Oct4-activating compound 1) can enhance the efficiency of reprogramming.

  • CX-4945 (Silmitasertib)

    CX-4945 is a potent and selective inhibitor of CK2 (casein kinase 2) with IC50 of 1 nM, less potent to Flt3, Pim1 and CDK1 (inactive in cell-based assay). Phase 1.

    Features:First clinical inhibitor of CK2.

  • Tacrolimus (FK506)

    FK-506 is a 23-membered macrolide lactone, it reduces peptidyl-prolyl isomerase activity by binding to the immunophilin FKBP12 (FK506 binding protein) creating a new complex.

  • Bendamustine HCl

    Bendamustine HCL is a DNA-damaging agent with IC50 of 50 μM.

  • Posaconazole

    Posaconazole is a sterol C14ɑ demethylase inhibitor with an IC50 of 0.25 nM.

    Features:Currently the most advanced candidate for the treatment of Chagas disease.

  • Cidofovir

    Cidofovir suppresses virus replication by selective inhibition of viral DNA synthesis.

  • Simvastatin

    Simvastatin is a competitive inhibitor of HMG-CoA reductase with Ki of 0.1-0.2 nM .

  • Streptozotocin (STZ)

    Streptozotocin is a glucosamine-nitrosourea derivative, which is a methylating, carcinogenic, antibiotic and diabetes inducing agent.

Recently Viewed Items

Tags: buy Dihydromyricetin | Dihydromyricetin ic50 | Dihydromyricetin price | Dihydromyricetin cost | Dihydromyricetin solubility dmso | Dihydromyricetin purchase | Dihydromyricetin manufacturer | Dihydromyricetin research buy | Dihydromyricetin order | Dihydromyricetin mouse | Dihydromyricetin chemical structure | Dihydromyricetin mw | Dihydromyricetin molecular weight | Dihydromyricetin datasheet | Dihydromyricetin supplier | Dihydromyricetin in vitro | Dihydromyricetin cell line | Dihydromyricetin concentration | Dihydromyricetin nmr
Contact Us