Dihydromyricetin

Dihydromyricetin (Ampelopsin, Ampeloptin) is a natural antioxidant flavonoid from Ampelopsis grossedentata.

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In DMSO USD 220 In stock
USD 170 In stock
USD 320 In stock
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Dihydromyricetin Chemical Structure

Dihydromyricetin Chemical Structure
Molecular Weight: 320.25

Validation & Quality Control

Customer Reviews(1)

Quality Control & MSDS

Related Compound Libraries

Dihydromyricetin is available in the following compound libraries:

Product Information

Product Description

Biological Activity

Description Dihydromyricetin (Ampelopsin, Ampeloptin) is a natural antioxidant flavonoid from Ampelopsis grossedentata.
LD50
In vitro Dihydromyricetin shows antioxidant activity as an effective scavenger of 1,1-diphenyl-2-picrylhydrazyl radical (DPPH). It also inhibits the increase of lipid peroxidation (LPO) values in linolei acid system catalyzed by FeSO4-edetic acid. [1] DHM (1 μM) as a novel anti-alcohol intoxication medication antagonizes both acute EtOH-induced potentiation of GABA(A)Rs and EtOH exposure/withdrawal-induced GABA(A)R plasticity and increases in GABA(A)R alpha4 subunit expression in hippocampus and cultured neurons. [2]
In vivo Dihydromyricetin (1 mg/kg, i.p.) counteracts acute alcohol (EtOH) intoxication, and also withdrawals signs in rats including tolerance, increased anxiety, and seizure susceptibity. [2] LD50: Mice 1.41g/kg (i.p.) [3]
Features

Protocol(Only for Reference)

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesBaboonDogMonkeyRabbitGuinea pigRatHamsterMouse
Weight (kg)121031.80.40.150.080.02
Body Surface Area (m2)0.60.50.240.150.050.0250.020.007
Km factor202012128653
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)
1

References

[1] Zhang YS, et al. Yao Xue Xue Bao, 2003, 38(4), 241-244.

[2] Shen Y, et al. J Neurosci, 2012, 32(1), 390-401.

Chemical Information

Download Dihydromyricetin SDF
Molecular Weight (MW) 320.25
Formula

C15H12O8

CAS No. 27200-12-0
Storage 3 years -20℃Powder
6 months-80℃in DMSO
Synonyms Ampeloptin
Solubility (25°C) * In vitro DMSO 64 mg/mL (199 mM)
Water <1 mg/mL (<1 mM)
Ethanol 64 mg/mL (199 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Name (2R,3R)-3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-2,3-dihydrochromen-4-one

Research Area

Customer Reviews (1)


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Rating
Source Food and Chemical Toxicology 50 (2012) 2508–2514. Dihydromyricetin purchased from Selleck
Method Enzymetic acitivity
Cell Lines mouse
Concentrations 3mM,5mL/Kg, Orally,
Incubation Time 3 hr
Results The DHM-treated groups also showed lower ethanol and acetaldehyde concentrations than that of the control group,however, 1 mM DHM did not affect the ADH and ALDH activities. The enhancing effects of taraxerone on ADH and ALDH activities were approximately 1.5 and 2 times higher than that of DHM at 3 and 5 mM treatments, respectively.

Product Citations (1)

Tech Support & FAQs

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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