Dihydromyricetin

Dihydromyricetin (Ampelopsin, Ampeloptin) is a natural antioxidant flavonoid from Ampelopsis grossedentata.

Price Stock Quantity  
In DMSO USD 220 In stock
USD 170 In stock
USD 320 In stock
USD 970 In stock
Bulk Inquiry

Massive Discount Available

Free Overnight Delivery on all orders over $ 500.

Dihydromyricetin Chemical Structure

Dihydromyricetin Chemical Structure
Molecular Weight: 320.25

Validation & Quality Control

Customer Product Validation(1)

Quality Control & MSDS

Product Information

  • Compare GABA Receptor Inhibitors
    Compare GABA Receptor Products
  • Research Area

Product Description

Biological Activity

Description Dihydromyricetin (Ampelopsin, Ampeloptin) is a natural antioxidant flavonoid from Ampelopsis grossedentata.
Targets GABAA receptor [1] GABAA receptor [2]
LD50
In vitro Dihydromyricetin shows antioxidant activity as an effective scavenger of 1,1-diphenyl-2-picrylhydrazyl radical (DPPH). It also inhibits the increase of lipid peroxidation (LPO) values in linolei acid system catalyzed by FeSO4-edetic acid. [1] DHM (1 μM) as a novel anti-alcohol intoxication medication antagonizes both acute EtOH-induced potentiation of GABA(A)Rs and EtOH exposure/withdrawal-induced GABA(A)R plasticity and increases in GABA(A)R alpha4 subunit expression in hippocampus and cultured neurons. [2]
In vivo Dihydromyricetin (1 mg/kg, i.p.) counteracts acute alcohol (EtOH) intoxication, and also withdrawals signs in rats including tolerance, increased anxiety, and seizure susceptibity. [2] LD50: Mice 1.41g/kg (i.p.) [3]
Features

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDog
Weight (kg)0.020.151.80.40.0810
Body Surface Area (m2)0.0070.0250.150.050.020.5
Km factor36128520
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)
1

References

[1] Zhang YS, et al. Yao Xue Xue Bao, 2003, 38(4), 241-244.

[2] Shen Y, et al. J Neurosci, 2012, 32(1), 390-401.

Chemical Information

Download Dihydromyricetin SDF
Molecular Weight (MW) 320.25
Formula

C15H12O8

CAS No. 27200-12-0
Storage 3 years -20℃powder
6 months-80℃in solvent
Synonyms Ampeloptin
Solubility (25°C) * In vitro DMSO 64 mg/mL (199.84 mM)
Ethanol 64 mg/mL (199.84 mM)
Water <1 mg/mL (<1 mM)
In vivo
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Name (2R,3R)-3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-2,3-dihydrochromen-4-one

Customer Product Validation (1)


Click to enlarge
Rating
Source Food Chem Toxicol 2012 50, 2508-2514. Dihydromyricetin purchased from Selleck
Method Enzymetic acitivity
Cell Lines mouse
Concentrations 3mM,5mL/Kg, Orally,
Incubation Time 3 hr
Results The DHM-treated groups also showed lower ethanol and acetaldehyde concentrations than that of the control group,however, 1 mM DHM did not affect the ADH and ALDH activities. The enhancing effects of taraxerone on ADH and ALDH activities were approximately 1.5 and 2 times higher than that of DHM at 3 and 5 mM treatments, respectively.

Product Use Citation (1)

Tech Support & FAQs

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

* Indicates a Required Field

Related GABA Receptor Products

  • Metoclopramide HCl

    Metoclopramide HCl is a selective dopamine D2 receptor antagonist, used for the treatment of nausea and vomiting.

  • Meclofenamate Sodium

    Meclofenamate Sodium is a dual COX-1/COX-2 inhibitor with IC50 of 40 nM and 50 nM, respectively, used in the treatment of joint, muscular pain, arthritis and dysmenorrhea.

  • LY2119620

    LY2119620 is a specific, and allosteric agonist of human M2 and M4 muscarinic acetylcholine receptors.

  • (+)-Bicuculline

    (+)-Bicuculline is a competitive antagonist of GABAA receptors with IC50 of 2 μM, also blocks Ca(2+)-activated potassium channels.

  • Flumazenil

    Flumazenil is a competitive GABAA receptor antagonist, used in the treatment of benzodiazepine overdoses.

  • Gabapentin

    Gabapentin is a GABA analogue, used to treat seizures and neuropathic pain.

  • Etomidate

    Etomidate is a GABAA receptor agonist, used as a short-acting anaesthetic agent or sedative.

  • Bemegride

    Bemegride is a central nervous system stimulant and antidote for barbiturate poisoning.

  • Gabapentin HCl

    Gabapentin HCl is a GABA analogue, used to treat seizures and neuropathic pain.

  • Baicalin

    Baicalin is a known prolyl endopeptidase inhibitor and affects the GABA receptors.

Recently Viewed Items

Tags: buy Dihydromyricetin | Dihydromyricetin supplier | purchase Dihydromyricetin | Dihydromyricetin cost | Dihydromyricetin manufacturer | order Dihydromyricetin | Dihydromyricetin distributor
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description
Contact Us