Catalog No.S2399 Synonyms: Ampeloptin
Molecular Weight(MW): 320.25
Dihydromyricetin (Ampelopsin, Ampeloptin) is a natural antioxidant flavonoid from Ampelopsis grossedentata.
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A. Cal27 cells transfected with GFP-LC3 plasmid were treated with different concentration of DHM for 24 h. The formation of GFP-LC3 puncta were examined using immunofluorescence and quantified. Scale bar 50 μm.
Oncotarget, 2016, 7(37):59691-59703. Dihydromyricetin purchased from Selleck.
ADH and ALDH expressions in 40% ethanol loaded mice for three hours. Group 1, 500 lM taraxerone; Group 2, 1 mM taraxerone; Group 3, 3 mM DHM (positive control); Group 4, DMSO (control); Group 5, saline. Taraxerone and DHM were dissolved in DMSO, and all treated samples (ethanol, taraxerone, DHM, DMSO, and saline) were administered orally (5 mL/kg body weight). The same letters denote significant differences at p < 0.05, and the error bar represents standard deviation.
Food Chem Toxicol 2012 50, 2508-2514. Dihydromyricetin purchased from Selleck.
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Choose Selective GABA Receptor Inhibitors
|Description||Dihydromyricetin (Ampelopsin, Ampeloptin) is a natural antioxidant flavonoid from Ampelopsis grossedentata.|
Dihydromyricetin shows antioxidant activity as an effective scavenger of 1,1-diphenyl-2-picrylhydrazyl radical (DPPH). It also inhibits the increase of lipid peroxidation (LPO) values in linolei acid system catalyzed by FeSO4-edetic acid.  DHM (1 μM) as a novel anti-alcohol intoxication medication antagonizes both acute EtOH-induced potentiation of GABA(A)Rs and EtOH exposure/withdrawal-induced GABA(A)R plasticity and increases in GABA(A)R alpha4 subunit expression in hippocampus and cultured neurons. 
|In vivo||Dihydromyricetin (1 mg/kg, i.p.) counteracts acute alcohol (EtOH) intoxication, and also withdrawals signs in rats including tolerance, increased anxiety, and seizure susceptibity.  LD50: Mice 1.41g/kg (i.p.) |
|In vitro||DMSO||64 mg/mL (199.84 mM)|
|Ethanol||64 mg/mL (199.84 mM)|
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Clinical Trial Information
|NCT Number||Recruitment||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT03606694||Not yet recruiting||Type 2 Diabetes Mellitus||University of Guadalajara||October 1 2018||Phase 2|
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