Dihydromyricetin (Ampelopsin, Ampeloptin) is a natural antioxidant flavonoid from Ampelopsis grossedentata.

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Dihydromyricetin Chemical Structure

Dihydromyricetin Chemical Structure
Molecular Weight: 320.25

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Product Description

Biological Activity

Description Dihydromyricetin (Ampelopsin, Ampeloptin) is a natural antioxidant flavonoid from Ampelopsis grossedentata.
Targets GABAA receptor [1] GABAA receptor [2]
In vitro Dihydromyricetin shows antioxidant activity as an effective scavenger of 1,1-diphenyl-2-picrylhydrazyl radical (DPPH). It also inhibits the increase of lipid peroxidation (LPO) values in linolei acid system catalyzed by FeSO4-edetic acid. [1] DHM (1 μM) as a novel anti-alcohol intoxication medication antagonizes both acute EtOH-induced potentiation of GABA(A)Rs and EtOH exposure/withdrawal-induced GABA(A)R plasticity and increases in GABA(A)R alpha4 subunit expression in hippocampus and cultured neurons. [2]
In vivo Dihydromyricetin (1 mg/kg, i.p.) counteracts acute alcohol (EtOH) intoxication, and also withdrawals signs in rats including tolerance, increased anxiety, and seizure susceptibity. [2] LD50: Mice 1.41g/kg (i.p.) [3]

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDog
Weight (kg)
Body Surface Area (m2)0.0070.0250.
Km factor36128520
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)


[1] Zhang YS, et al. Yao Xue Xue Bao, 2003, 38(4), 241-244.

[2] Shen Y, et al. J Neurosci, 2012, 32(1), 390-401.

Chemical Information

Download Dihydromyricetin SDF
Molecular Weight (MW) 320.25


CAS No. 27200-12-0
Storage 3 years -20℃powder
6 months-80℃in solvent
Synonyms Ampeloptin
Solubility (25°C) * In vitro DMSO 64 mg/mL (199.84 mM)
Ethanol 64 mg/mL (199.84 mM)
Water <1 mg/mL (<1 mM)
In vivo
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Name (2R,3R)-3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-2,3-dihydrochromen-4-one

Customer Product Validation (1)

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Source Food Chem Toxicol 2012 50, 2508-2514. Dihydromyricetin purchased from Selleck
Method Enzymetic acitivity
Cell Lines mouse
Concentrations 3mM,5mL/Kg, Orally,
Incubation Time 3 hr
Results The DHM-treated groups also showed lower ethanol and acetaldehyde concentrations than that of the control group,however, 1 mM DHM did not affect the ADH and ALDH activities. The enhancing effects of taraxerone on ADH and ALDH activities were approximately 1.5 and 2 times higher than that of DHM at 3 and 5 mM treatments, respectively.

Product Use Citation (1)

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
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