Home Neuronal Signaling Beta Amyloid inhibitor Tabersonine hydrochloride For research use only.

Tabersonine hydrochloride

Tabersonine, an ingredient extracted from the bean of Voacanga africana, is a potent inhibitor against Aβ(1−42) aggregation and toxicity.

Tabersonine hydrochloride Chemical Structure

Tabersonine hydrochloride Chemical Structure

CAS: 29479-00-3

Purity & Quality Control

Batch: Purity: 99.58%
99.58

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Signaling Pathway

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Biological Activity

Description Tabersonine, an ingredient extracted from the bean of Voacanga africana, is a potent inhibitor against Aβ(1−42) aggregation and toxicity.
Targets
Aβ(1−42) aggregation [1]
In vitro
In vitro Tabersonine disrupts Aβ(1−42) aggregation and ameliorates Aβ aggregate-induced cytotoxicity. It binds to Aβ(1−42) oligomers more strongly than to Aβ(1−42) monomers with Kd values of 69 μM and 535 μM, respectively[1].
Cell Research Cell lines SH-SY5Y cell
Concentrations 10 μM
Incubation Time 24 h
Method

The cultured cells were transferred to a sterile 96-well plate with approximately 1×104 cells/well. Cells acclimatized overnight in the media in a humidified incubator under 5% CO2 at 37℃. Aβ(1−42)solutions and Aβ(1−42)−tabersonine mixtures were preincubated at 37℃ for different times, and the resultant solutions were mixed with the SH-SY5Y cells for 24 h. The viability of the SH-SY5Y cells exposed to each solution was determined with MTT assay. Cell viability was estimated by dividing the absorbance of wells containing samples by that of wells containing only cell culture media.
In Vivo
In vivo The biocompatibility and small size essential for permeating the blood−brain barrier make tabersonine a potential therapeutic drug candidate for treating Alzheimer's disease (AD)[1].

Chemical Information & Solubility

Molecular Weight 372.89 Formula

C21H24N2O2.HCl
CAS No. 29479-00-3 SDF Download Tabersonine hydrochloride SDF
Smiles CCC12CC(=C3C4(C1N(CC4)CC=C2)C5=CC=CC=C5N3)C(=O)OC.Cl
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 75 mg/mL ( (201.13 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 25 mg/mL

Water : Insoluble


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In vivo
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In vivo Formulation Calculator

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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