Salidroside

Catalog No.S2396

Salidroside, a phenylpropanoid glycoside isolated from Rhodiola rosea, has been reported to have a broad spectrum of pharmacological properties.

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Salidroside Chemical Structure

Salidroside Chemical Structure
Molecular Weight: 300.3

Validation & Quality Control

Quality Control & MSDS

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Product Description

Biological Activity

Description Salidroside, a phenylpropanoid glycoside isolated from Rhodiola rosea, has been reported to have a broad spectrum of pharmacological properties.
LD50
In vitro Salidroside inhibits the growth of various human cancer cell lines in concentration- and time-dependent manners, and the sensitivity to salidroside is different in those cancer cell lines. Salidroside could cause G1-phase or G2-phase arrest in different cancer cell lines, meanwhile, salidroside resultes in a decrease of CDK4, cyclin D1, cyclin B1 and Cdc2, and upregulates the levels of p27(Kip1) and p21(Cip1). [1] Salidroside also alleviates cell viability loss and apoptotic cell death induced by H(2)O(2) stimulation in cultured NGF-differentiated PC12 cells by activating ERK1/2 pathway and inhibiting caspase-3 activation. [2] Salidroside activates the PI3K/Akt pathway resulting in protective effects against MPP(+)-induced apoptosis in PC12 cells, which may be used in the treatment of Parkinson's disease (PD). [3]
In vivo Salidroside (20, 50 and 100 mg/kg) protects liver tissue from the oxidative stress elicited by D-galactosamine and lipopolysaccharide. [4]
Features

Protocol(Only for Reference)

1

References

[1] Hu X, et al. Cell Biol Toxicol, 2010, 26(6), 499-507.

[2] Yu S, et al. J Mol Neurosci, 2010, 40(3), 321-331.

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Chemical Information

Download Salidroside SDF
Molecular Weight (MW) 300.3
Formula

C14H20O7

CAS No. 10338-51-9
Storage 3 years -20℃Powder
6 months-80℃in DMSO
Synonyms Rhodioloside

Research Area

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