Home PI3K/Akt/mTOR mTOR activator Salidroside

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Salidroside mTOR activator

Cat.No.S2396

Salidroside (Rhodioloside), a phenylpropanoid glycoside isolated from Rhodiola rosea, has been reported to have a broad spectrum of pharmacological properties. This compound is a prolyl endopeptidase inhibitor. It alleviates cachexia symptoms in mouse models of cancer cachexia via activating mTOR signalling. This chemical protects dopaminergic neurons by enhancing PINK1/Parkin-mediated mitophagy.
Salidroside mTOR activator Chemical Structure

Chemical Structure

Molecular Weight: 300.3

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Quality Control

Batch: Purity: 99.98%
99.98

Solubility

In vitro
Batch:

DMSO : 60 mg/mL (199.8 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : 60 mg/mL

Ethanol : 4 mg/mL

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In vivo
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Chemical Information, Storage & Stability

Molecular Weight 300.3 Formula

C14H20O7

 Storage (From the date of receipt)
CAS No. 10338-51-9 Download SDF Storage of Stock Solutions

Synonyms Rhodioloside Smiles C1=CC(=CC=C1CCOC2C(C(C(C(O2)CO)O)O)O)O

Mechanism of Action

In vitro
Salidroside inhibits the growth of various human cancer cell lines in concentration- and time-dependent manners, and the sensitivity to this compound is different in those cancer cell lines. It could cause G1-phase or G2-phase arrest in different cancer cell lines, meanwhile, this compound resultes in a decrease of CDK4, cyclin D1, cyclin B1 and Cdc2, and upregulates the levels of p27(Kip1) and p21(Cip1). This chemical also alleviates cell viability loss and apoptotic cell death induced by H(2)O(2) stimulation in cultured NGF-differentiated PC12 cells by activating ERK1/2 pathway and inhibiting caspase-3 activation. It activates the PI3K/Akt pathway resulting in protective effects against MPP(+)-induced apoptosis in PC12 cells, which may be used in the treatment of Parkinson's disease (PD).
In vivo
Salidroside (20, 50 and 100 mg/kg) protects liver tissue from the oxidative stress elicited by D-galactosamine and lipopolysaccharide.
References
  • [4] https://pubmed.ncbi.nlm.nih.gov/19814871/

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