Catalog No.S4738 Synonyms: Arctigenin-4-Glucoside, NSC 315527
Molecular Weight(MW): 534.55
Arctiin acts on an agonists of the adiponectin receptor 1 with anti-cancer effects.
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|Description||Arctiin acts on an agonists of the adiponectin receptor 1 with anti-cancer effects.|
Arctiin induces growth inhibition and dephosphorylates the tumor-suppressor retinoblastoma protein in human immortalized keratinocyte HaCaT cells. The growth inhibition caused by arctiin is associated with the downregulation of cyclin D1 protein expression. The arctiin-induced suppression of cyclin D1 protein expression occurs in various types of human tumor cells, including osteosarcoma, lung, colorectal, cervical and breast cancer, melanoma, transformed renal cells and prostate cancer.
|In vivo||Arctiin has anti-cancer properties in animal models. arctiin has a remarkable anti-tumor-promoting effect as seen in a two-stage carcinogenesis test of mouse skin tumors induced by 7,12-dimethylbenz[α]anthracene(DMBA) as an initiator and 12-Otetradecanoyl phorbol-13-acetate (TPA) as a promoter by topical and oral administration. It also has a protective effect on 2-amino-1-methyl-6- phenylimidazo[4,5-β]pyridine (PhIP)-induced carcinogenesis particularly in the mammary gland during the promotion period. Arctiin is orally effective against either IFV-inoculated normal or 5-fluorouracil (5-FU)-treated mice.|
|In vitro||DMSO||100 mg/mL (187.07 mM)|
|Ethanol||100 mg/mL (187.07 mM)|
|Water||40 mg/mL (74.82 mM)|
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
|Synonyms||Arctigenin-4-Glucoside, NSC 315527|
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