Oleanolic Acid

Catalog No.S2334

Oleanolic Acid is a non-toxic, hepatoprotective triterpenoid found in Phytolacca Americana, which exerts antitumor and antiviral properties.

Price Stock Quantity  
In DMSO USD 70 In stock
USD 50 In stock
Bulk Inquiry

Massive Discount Available

Free Overnight Delivery on all orders over $ 500.

Oleanolic Acid Chemical Structure

Oleanolic Acid Chemical Structure
Molecular Weight: 456.7

Validation & Quality Control

Quality Control & MSDS

Product Information

Product Description

Biological Activity

Description Oleanolic Acid is a non-toxic, hepatoprotective triterpenoid found in Phytolacca Americana, which exerts antitumor and antiviral properties.
LD50
In vitro Oleanolic Acid is a non-toxic, hepatoprotective triterpenoid found in Phytolacca Americana which exerts antitumor and antiviral properties. Oleanolic acid is effective in protecting against chemically induced liver injury in laboratory animals. Oleanolic acid are relatively non-toxic, and has been used in cosmetics and health products. [1] Oleanolic acid was found to exhibit weak anti-HIV and weak anti-HCV activities, but more potent synthetic analogs are being investigated as potential drugs. [2]
In vivo
Features

Protocol(Only for Reference)

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesBaboonDogMonkeyRabbitGuinea pigRatHamsterMouse
Weight (kg)121031.80.40.150.080.02
Body Surface Area (m2)0.60.50.240.150.050.0250.020.007
Km factor202012128653
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)
1

References

[1] Liu J, J Ethnopharmacol, 1995, 49(2), 57-68.

[2] Mengoni F, Planta Med, 2002, 68(2), 111-114.

Clinical Trial Information( data from http://clinicaltrials.gov, updated on 2014-10-24)

NCT Number Recruitment Conditions Sponsor
/Collaborators
Start Date Phases
NCT01674946 Completed Echolocation University Hospital, Basel, Switzerland September 2011 Phase 1

Chemical Information

Download Oleanolic Acid SDF
Molecular Weight (MW) 456.7
Formula

C30H48O3

CAS No. 508-02-1
Storage 3 years -20℃Powder
6 months-80℃in DMSO
Synonyms Caryophyllin
Solubility (25°C) * In vitro DMSO 21 mg/mL (45 mM)
Water <1 mg/mL (<1 mM)
Ethanol 7 mg/mL (15 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Research Area

Tech Support & FAQs

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

* Indicates a Required Field

Related Others Products

  • PTC-209

    PTC-209 is a potent and selective BMI-1 inhibitor with IC50 of 0.5 μM, and results in irreversible reduction of cancer-initiating cells (CICs).

  • (S)-crizotinib

    (S)-crizotinib, the (S)-enantiomer of crizotinib, is a potent MTH1 (NUDT1) inhibitor with IC50 of 72 nM.

  • AZ191

    AZ191 is a potent and selective DYRK1B inhibitor with IC50 of 17 nM, about 5- and 110-fold selectivity over DYRK1A and DYRK2, respectively.

  • CX-4945 (Silmitasertib)

    CX-4945 (Silmitasertib) is a potent and selective inhibitor of CK2 (casein kinase 2) with IC50 of 1 nM, less potent to Flt3, Pim1 and CDK1 (inactive in cell-based assay). Phase 1/2.

    Features:First clinical inhibitor of CK2.

  • Tacrolimus (FK506)

    FK-506 is a 23-membered macrolide lactone, it reduces peptidyl-prolyl isomerase activity by binding to the immunophilin FKBP12 (FK506 binding protein) creating a new complex.

  • Verteporfin

    Verteporfin is a potent second-generation photosensitizing agent derived from porphyrin.

  • Bendamustine HCl

    Bendamustine HCL is a DNA-damaging agent with IC50 of 50 μM.

  • Cyclosporin A

    Cyclosporin A is an immunosuppressive agent, binds to the cyclophilin and then inhibits calcineurin with IC50 of 7 nM, widely used in organ transplantation to prevent rejection.

  • Cyclophosphamide Monohydrate

    Cyclophosphamide Monohydrate is a nitrogen mustard alkylating agent, it attaches the alkyl group to the guanine base of DNA.

  • Cabazitaxel

    Cabazitaxel (XRP6258) is a semi-synthetic derivative of a natural taxoid.

    Features:A semi-synthetic derivative of a natural taxoid.

Recently Viewed Items

Tags: buy Oleanolic Acid | Oleanolic Acid supplier | purchase Oleanolic Acid | Oleanolic Acid cost | Oleanolic Acid manufacturer | order Oleanolic Acid | Oleanolic Acid distributor
Contact Us