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D-Aspartic acid

Name: D-Aspartic acid
Brand: Selleck Chemicals
SKU: S5129
Rating: 5 (1 reviews)

Synonyms: Asp, Aminosuccinic acid, asparagic acid, asparaginic acid

Catalog No.S5129 Purity: 98%

D-Aspartic acid (D-Asp, Aminosuccinic acid, asparagic acid, asparaginic acid) is an endogenous amino acid occurring in several tissues and cells of both invertebrates and vertebrates. It can regulate testosterone synthesis and may act on a stimulatory receptor (NMDA).

D-Aspartic acid Chemical Structure

CAS: 1783-96-6

Purity & Quality Control

Batch: S512901 5%TFA] 6.02 mg/mL] false] DMSO] 0.01 mg/mL] false] Water] Insoluble] false Purity: 98%

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Biological Activity

Description	D-Aspartic acid (D-Asp, Aminosuccinic acid, asparagic acid, asparaginic acid) is an endogenous amino acid occurring in several tissues and cells of both invertebrates and vertebrates. It can regulate testosterone synthesis and may act on a stimulatory receptor (NMDA).

In vitro
In vitro	D-aspartate (D-Asp) is an endogenous amino acid present in vertebrate tissues, with particularly high levels in the testis. In vitro studies have demonstrated that D-Asp up-regulates testosterone production in Leydig cells by enhancing expression of the steroidogenic acute regulatory protein. Besides testosterone release, D-Asp induced E2 synthesis through aromatase activation^[1].
Cell Research	Cell lines	GC-1 cells
	Concentrations	200 μM
	Incubation Time	30 min, 2 h, 4 h
	Method	Cultures were carried on in the presence of D-Asp (200 μM; diluted in distilled H2O) in different time exposure of the amino acid (30 min, 2 h, 4 h). Control cultures were treated with vehicle alone. At the end of the incubation period, cells were rinsed in PBS, harvested by trypsinization, collected by centrifugation at 1,000g for 10 min and immediately frozen at 80°C for biochemical analyses.

In Vivo
In vivo	In vivo studies indicate that D-Asp indirectly stimulates spermatogenesis through the hypothalamic-pituitary-gonadal axis. The oral and/or intraperitoneal D-Asp administration to adult rats induced an increase of serum progesterone and LH as well as an increase of testis/serum testosterone levels, whereas 17β-estradiol (E2) levels did no change^[1]. D-aspartic acid has significant analgesic activity^[2].
Animal Research	Animal Models	Inbred albino BALB/C mice
	Dosages	55, 115, and 230 mg/kg
	Administration	i.p.

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-01-11)
NCT05847179	Not yet recruiting	Werner Syndrome	PRG Science & Technology Co. Ltd.	January 1 2025	Phase 2
NCT05777512	Recruiting	Bronchopulmonary Dysplasia	Boston Children''s Hospital\|Beth Israel Deaconess Medical Center	October 2024	Not Applicable
NCT05638568	Not yet recruiting	Surfactant Deficiency Syndrome Neonatal\|Respiratory Distress Syndrome Newborn\|Bronchopulmonary Dysplasia	Rigshospitalet Denmark\|Odense University Hospital\|Aalborg University Hospital\|Aarhus University Hospital\|Holbaek Sygehus	July 1 2024	Not Applicable
NCT03468556	Not yet recruiting	NASH - Nonalcoholic Steatohepatitis	Sinew Pharma Inc.	March 1 2024	Phase 2
NCT06039644	Not yet recruiting	Breast Cancer	GenMont Biotech Incorporation\|Mackay Memorial Hospital	March 1 2024	Not Applicable
NCT05951231	Not yet recruiting	Liver Transplant; Complications\|Transplant; Failure Liver\|Transplant Dysfunction\|Transplant; Complication Rejection\|Transplant\|Liver Metastases\|Liver Cancer	Oslo University Hospital\|South-Eastern Norway Regional Health Authority	February 2024	Not Applicable

References

Chemical Information & Solubility

Molecular Weight	133.10	Formula	C₄H₇NO₄
CAS No.	1783-96-6	SDF	Download D-Aspartic acid SDF
Smiles	C(C(C(=O)O)N)C(=O)O
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

5%TFA : 6.02 mg/mL

DMSO : 0.01 mg/mL ( (0.07 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

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In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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