Biochanin A

Synonyms: 4-Methylgenistein

Biochanin A (4-Methylgenistein), an O-methylated isoflavone from Trifolium pratense, inhibits protein tyrosine kinase (PTK) of epidermal growth factor receptor with IC50 values of 91.5 μM.

Biochanin A Chemical Structure

Biochanin A Chemical Structure

CAS: 491-80-5

Selleck's Biochanin A has been cited by 5 publications

Purity & Quality Control

Batch: Purity: 99.69%
99.69

Biochanin A Related Products

Signaling Pathway

Choose Selective FAAH Inhibitors

Biological Activity

Description Biochanin A (4-Methylgenistein), an O-methylated isoflavone from Trifolium pratense, inhibits protein tyrosine kinase (PTK) of epidermal growth factor receptor with IC50 values of 91.5 μM.
Targets
FAAH (rat) [2] FAAH (mouse) [1] FAAH (human) [2] EGFR [1]
1.4 μM 1.8 μM 2.4 μM 91.5 μM
In vitro
In vitro Biochanin A has been reported to inhibit protein tyrosine kinase (PTK) of epidermal growth factor receptor with IC50 values of 91.5 μM [1] Biochanin A inhibits the hydrolysis of 0.5 μM anandamide by mouse, rat and human fatty acid amide hydrolase (FAAH) with IC50 values of 1.8, 1.4 and 2.4 μM respectively. [2] Biochanin A inhibits both serum and EGF-stimulated growth of LNCaP and DU-145 cells (IC50 values from 8.0 to 27 micrograms/ml for serum and 4.3 to 15 micrograms/ml for EGF), but has no significant effect of the EGF receptor tyrosine autophosphorylation. [3]
In Vivo
In vivo LD50: Mice 63mg/kg (i.p.) [4]

Chemical Information & Solubility

Molecular Weight 284.26 Formula

C16H12O5

CAS No. 491-80-5 SDF Download Biochanin A SDF
Smiles COC1=CC=C(C=C1)C2=COC3=CC(=CC(=C3C2=O)O)O
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 56 mg/mL ( (197.0 mM); Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 16 mg/mL

Water : Insoluble


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In vivo
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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