Abbreviations

Routes of drug administration

Route Abbreviation Description
Intracerebroventricular i.c.v. Into the ventricles of the brain
Intra-arterial i.a. Into the lumen of an artery
Intracerebral i.c. Into the brain
Intradermal i.d. Into the dermal layer of the skin
Intramuscular i.m. Into a skeletal muscle
Intragastric i.g. Into the stomach
Intraperitoneal i.t. Into the spinal canal
Intravenous i.v. Into a vein
Oral p.o. By mouth
Subcutaneous s.c. Under the skin
  q.d. once a day
  b.i.d. twice a day
  t.i.d. three times a day

Targets

Abbreviation Description
Abl V-abl Abelson murine leukemia viral oncogene homolog 1
ALK anaplastic lymphoma kinase
ATM Ataxia telangiectasia mutated
B-Raf B-Raf proto-oncogene serine/threonine-protein kinase (B-RAF), also known as V-raf murine sarcoma viral oncogene homolog B1
Bcl-2 B-cell lymphoma 2
bcr breakpoint cluster region
Caspase cysteine-aspartic proteases or cysteine-dependent aspartate-directed proteases
CCR5 co-receptors chemokine receptor 5
CDK Cyclin-dependent kinase
CFTR potentiator Cystic fibrosis transmembrane conductance regulator
CTSK Cathepsin K, abbreviated CTSK
c-Kit CD117, also called KIT or C-kit receptor
c-Met mesenchymal-epithelial transition factor
DNA-PK DNA-dependent protein kinase
DPP-4 Dipeptidyl peptidase-4
EGFR Epidermal growth factor receptor
Factor Xa also known by the eponym Stuart-Prower factor or as prothrombinase
FGFR Fibroblast growth factor receptor
FLT-3 fms-like tyrosine kinase receptor-3
FTS farnesyl thiosalicylic
GSK-3 Glycogen synthase kinase 3
HER2 Human Epidermal growth factor Receptor 2
Hedgehog an intercellular signaling molecule called Hedgehog (Hh)
HDAC Histone deacetylase
HIF Hypoxia-inducible factor
HSP-70 heat-shock protein-70
HSP-90 heat-shock protein-90
IGF-1R Insulin-like growth factor 1 receptor
JAK Janus kinase
JNK c-Jun N-terminal kinases
Ksp Kinesin spindle protein
MAPK Mitogen-activated Protein Kinase
MEK MAPK/ERK kinase
mGlu2/3 receptors metabotropic glutamate receptors
mTOR Mammalian target of rapamycin
NF-kB Nuclear factor κ B
p38 MAPK p38 Mitogen-activated Protein Kinase
p53 protein 53 or tumor protein 53
PARP Poly (ADP-ribose) polymerase
PDGFR platelet-derived growth factor receptor
PDK-1 phosphoinositide-dependent kinase-1
Rho ρ factor
PI3K Phosphatidylinositol 3-kinases
PKC protein kinase C
PLK Polo-like kinase
Ras renin-angiotensin system
RNA Polymerase I RNAP or RNApol
S1PR1 sphingosine-1-phosphate receptor 1,also known as S1P1 or EDG1 (endothelial differentiation gene 1)
sPLA2 Secreted phospholipases A2
Src Rous sarcoma oncogene cellular homolog
Stat Signal Transducers and Activator of Transcription
Survivin also called baculoviral inhibitor of apoptosis repeat-containing 5 or BIRC5
TGF-beta Transforming growth factor
TNF-alpha Tumor necrosis factors
VEGFR-PDGFR Vascular Endothelial Growth Factor Receptor -platelet derived growth factor receptor
Wee1 Small cell protein, a mitotic inhibitor kinase
Wnt a combination of Wg (wingless) and Int