Catalog No.S4690 Synonyms: Aescin
Molecular Weight(MW): 1131.26
Escin is a mixture of saponins with anti-inflammatory, vasoconstrictor and vasoprotective effects found in Aesculus hippocastanum(the horse chestnut).
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|Description||Escin is a mixture of saponins with anti-inflammatory, vasoconstrictor and vasoprotective effects found in Aesculus hippocastanum(the horse chestnut).|
Escin is effective to inhibit pancreatic cancer cell proliferation as a single agent. However, escin has minimal effect on normal rat skeletal muscle cells. Escin potentiates the proliferation-inhibiting and apoptosis-inducing effect of gemcitabine in both BxPC-3 and PANC-1 cell lines in vitro. It also down-regulates constitutive as well as gemcitabine-induced activation of NF-kB and its downstream gene products in pancreatic cancer cells in vitro.
|In vivo||Escin augments therapeutic effect of gemcitabine in BxPC-3 xenografts in nude mice. They have significant synergistic effects on suppressing the growth of pancreatic tumors, inhibiting the proliferation and inducing apoptosis of tumors. Escin potentiates the inhibiting effect of gemcitabine on NF-kB and NF-kB-regulated gene products in BxPC-3 xenografts in nude mice.|
|In vitro||DMSO||66 mg/mL (58.34 mM)|
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