Spermidine trihydrochloride

Catalog No.S3653 Synonyms: 4-Azaoctamethylenediamine trihydrochloride

Spermidine trihydrochloride Chemical Structure

Molecular Weight(MW): 254.63

Spermidine, a natural polyamine produced from putrescine and decarboxylated S-adenosylmethionine (dcSAM) by spermidine synthase, is a novel autophagy inducer and negatively modulates N-methyl-d-aspartate (NMDA).

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Biological Activity

Description Spermidine, a natural polyamine produced from putrescine and decarboxylated S-adenosylmethionine (dcSAM) by spermidine synthase, is a novel autophagy inducer and negatively modulates N-methyl-d-aspartate (NMDA).
Targets
Autophagy [1]
()
NMDAR [1]
()
In vitro

Spermidine induces autophagy in cultured yeast and mammalian cells, as well as in nematodes and flies[1].

In vivo Spermidine at 200 μg/mouse, intracerebellar injection (icb), does not alter basal cGMP levels. Spermidine attenuates responses mediated through the N-methyl-D-aspartate (NMDA), NMDA-associated glycine receptor and quisqualate receptors. Spermidine is widely distributed in neural and non-neural tissues and has been shown to play a key role in cell differentiation and growth[2].

Protocol

Solubility (25°C)

In vitro Water 50 mg/mL (196.36 mM)
DMSO 30 mg/mL (117.81 mM)
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 254.63
Formula

C7H19N3.3ClH

CAS No. 334-50-9
Storage powder
in solvent
Synonyms 4-Azaoctamethylenediamine trihydrochloride

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID