Panaxatriol

Panaxatriol is a triterpene sapogenin originally found in species of Panax (ginseng) and exhibits anti-inflammatory, hepatoprotective, anti-arrhythmic, and antioxidative activities.

Panaxatriol Chemical Structure

Panaxatriol Chemical Structure

CAS: 32791-84-7

Purity & Quality Control

Batch: Purity: 99.85%
99.85

Panaxatriol Related Products

Biological Activity

Description Panaxatriol is a triterpene sapogenin originally found in species of Panax (ginseng) and exhibits anti-inflammatory, hepatoprotective, anti-arrhythmic, and antioxidative activities.
In vitro
In vitro Panaxatriol exerts dose-dependent cytotoxic effects on prostate DU-15 cancer cells. The IC50 of panaxatriol is 30 μM. Panaxatriol is found to exert its anticancer activity through induction of apoptosis. The apoptosis of DU-15 cancer cells is prompted by ROS-mediated alterations in mitochondrial membrane potential. Additionally, panaxatriol induces sub-G1 cell cycle arrest and suppresses the DU-15 cell migration ability in a concentration-dependent manner[1].
Cell Research Cell lines DU-15 cancer cells
Concentrations 0-120 μM
Incubation Time 48-72 h
Method

The cytotoxic effect of panaxatriol against prostate cancer cells is determined by MTT assay. DU-15 cells are cultured at the density of 1×106 cells per well in 96 well plates for 12 hrs and then treated with varying concentrations of panaxatriol (0-120 μM) for 48-72 hrs. MTT solution (20 μl) is added to each well. After-wards, 500 μl of DMSO is added to solubilize MTT formazan crystals, and ELISA plate reader is used for the determination of optical density.

In Vivo
In vivo Panaxatriol can relieve myelosuppression induced by radiation injury[2].
Animal Research Animal Models albino mice
Dosages 200 mg/kg
Administration oral administration

Chemical Information & Solubility

Molecular Weight 476.73 Formula

C30H52O4

CAS No. 32791-84-7 SDF Download Panaxatriol SDF
Smiles CC1(CCCC(O1)(C)C2CCC3(C2C(CC4C3(CC(C5C4(CCC(C5(C)C)O)C)O)C)O)C)C
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 95 mg/mL ( (199.27 mM); Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


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In vivo
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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