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Salicylic acid COX inhibitor

Name: Salicylic acid
Brand: Selleck Chemicals
SKU: S4539
Availability: InStock
Rating: 5 (2 reviews)

Cat.No.S4539

Salicylic acid (2-Hydroxybenzoic acid) is a beta hydroxy acid that occurs as a natural compound in plants which is an inhibitor of ethylene biosynthesis and cyclooxygenase activity.This compound can be used to induce animal models of Gastric and Intestinal Ulcers.

Chemical Structure

Molecular Weight: 138.12

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Quality Control

Batch: Purity: 99.95%

99.95

Related Targets	Adrenergic Receptor AChR 5-HT Receptor Calcium Channel Histamine Receptor Dopamine Receptor GABA Receptor TRP Channel Cholinesterase (ChE) GluR
Other COX Inhibitors	NS-398 (NS398) Paeoniflorin (NSC 178886) Lumiracoxib Xanthohumol Bufexamac Nimesulide Ginsenoside Rd Oroxin B Phenacetin Tolfenamic Acid

Solubility

In vitro
Batch:

DMSO : 27 mg/mL (195.48 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 27 mg/mL

Water : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

% Tween 80

% ddH₂O

% DMSO

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	138.12	Formula	C₇H₆O₃	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	69-72-7	Download SDF		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent

Mechanism of Action

Targets/IC₅₀/Ki	Ethylene biosynthesis COX
In vitro	Salicylic acid (SA) is a phenolic phytohormone involved in plant defence against pathogens. It significantly stimulated PON1 activity in a concentration dependent manner.
In vivo	Although oral salicylic acid (5.5 mg/kg body weight) during the Hg(0) exposure did not reduce the Hg levels in these organs, it effectively counteracted the Hg(0)-induced growth inhibition, and improved the behavioral performance, accompanied by a series of ameliorations in the antioxidative defense and anti-inflammatory response.
References	[1] https://pubmed.ncbi.nlm.nih.gov/9187256/ [2] https://pubmed.ncbi.nlm.nih.gov/23742082/ [3] https://www.researchgate.net/publication/260752504_In_vitro_Effects_of_Salicylic_Acid_on_Plasma_Paraoxonase_1_Activity [4] https://pubmed.ncbi.nlm.nih.gov/16666393/

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT05712837	Completed	Acne Vulgaris	Combined Military Hospital Abbottabad	June 1 2022	Not Applicable
NCT05166096	Completed	Healthy	Rhoshan Pharmaceuticals Inc	December 3 2021	Phase 1
NCT04811625	Completed	Healthy Volunteers	PLx Pharma	April 28 2021	Phase 4
NCT04792723	Unknown status	Cardiovascular Diseases	Vita Green Health Products Co. Ltd	March 5 2021	Phase 1

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