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Angiogenesis/Receptor Tyrosine Kinases Pathway



Angiogenesis is the process of the growth of new blood vessels from pre-existing vessels. Angiogenesis can be induced by solid tumor growth. In the meantime, angiogenesis provides solid tumor with oxygen and nutrients to make it reach a certain size.

Receptor tyrosine kinases (RTK)s are the high-affinity cell surface receptors that transmit extracellular signals into the cell. Many RTK classes have been identified, such as EGFR family, FGFR family, VEGFR family, RET receptor family and Eph receptor Family. Overexpression or functional mutations of receptor tyrosine kinases lead to uncontrolled cell growth and cancer.

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