Gallic acid

Catalog No.S4603 Synonyms: 3,4,5-Trihydroxybenzoic acid, Gallate, Benzoic acid

Gallic acid Chemical Structure

Molecular Weight(MW): 170.12

Gallic acid is an organic acid found in a variety of foods and herbs that are well known as powerful antioxidants.

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Biological Activity

Description Gallic acid is an organic acid found in a variety of foods and herbs that are well known as powerful antioxidants.
In vitro

Gallic acid does not protect against H(2)O(2)-induced PC12 cell death. It reduced the viability of PC12 cells in a dose-dependent manner. Gallic acid also induces cleavage of poly (ADP-ribose) polymerase, which is strongly related to apoptosis in neurons. Gallic acid induces the phosphorylation of c-Jun N-terminal protein kinase (JNK) and the downregulation of Bcl-2 in PC12 cells. Gallic acid leads to a progressive reduction in the viability of vector-transfected PC12 cells, which is delayed in PC12 cells that overexpressed Bcl-2[2].

In vivo Gallic acid effectively protects rat erythrocytes. The antioxidant effect of the compound at the tested dosage in vivo was more prevalent than its prooxidative effects. Gallic acid has ameliorative effect on lipid peroxidation in vivo[1].

Protocol

Cell Research:[2]
+ Expand
  • Cell lines: PC12 cells
  • Concentrations: 25 or 50 μM
  • Incubation Time: 24 h
  • Method: Cell viability is measured using the MTT assay. PC12 cells are incubated at 37◦C with H2O2 or gallic acid at different concentrations for 24 h with or without pretreatment with resveratrol. They are then treated with the MTT solution (final concentration, 1 mg/mL) for 2 h. The dark-blue formazan crystals that formed in intact cells are dissolved in DMSO, and the absorbance at 570 nm is measured using a micro-ELISA reader.
    (Only for Reference)
Animal Research:[1]
+ Expand
  • Animal Models: Male Wistar rats
  • Formulation: isotonic saline solution
  • Dosages: 10 mg/kg and 20 mg/kg
  • Administration: i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 34 mg/mL (199.85 mM)
Ethanol 34 mg/mL (199.85 mM)
Water 7 mg/mL (41.14 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 170.12
Formula

C7H6O5

CAS No. 149-91-7
Storage powder
Synonyms 3,4,5-Trihydroxybenzoic acid, Gallate, Benzoic acid

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

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Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

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Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID