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Hyodeoxycholic acid (HDCA) Chemical Structure
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Biological Activity
Hyodeoxycholic(HDCA) acid is a secondary bile acid, one of the metabolic byproducts of intestinal bacteria. In rat intestinal microflora hyodeoxycholic acid is produced by a gram-positive rod—termed HDCA-1—from several isomers of hyocholic acid and muricholic acid. In pigs with a normal gastrointestinal flora the majority of hyodeoxycholic acid found in bile is of secondary nature, but a small amount was also found in germ free pigs, which supports the hypothesis that HDCA may be a primary bile acid in this species. In healthy humans only traces of HDCA have been found in urine, but in patients with cholestatic liver disease or intestinal malabsorption a significant amount has been found excreted. Hyodeoxycholic acid undergoes glucuronidation in human liver and kidneys. [1]
Chemical Information
| Molecular Weight (WM): | 392.57 |
|---|---|
| Formula: | C24H40O4 |
| CAS No.: | 83-49-8 |
| Synonyms: |
3α,6α-Dihydroxy-5β-cholan-24-oic acid, HDCA
|
| Dissolve in (25°C): | DMSO ≥79mg/mL |
| Water <1mg/mL | |
| Ethanol ≥79mg/mL | |
| Storage: | 2 years-20°CPowder |
| 1 week-4°Cin DMSO | |
| 1 month-80°in DMSO |
Quality Control & MSDS
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