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Chebulagic acid COX inhibitor

Name: Chebulagic acid
Brand: Selleck Chemicals
SKU: E0226
Availability: InStock
Rating: 5 (1 reviews)

Cat.No.E0226

Chebulagic acid, isolated form Terminalia chebula Retz, is a reversible and non-competitive inhibitor of maltase with a Ki value of 6.6 μM. This compound shows potent anti-inflammatory effects in LPS-stimulated RAW 264.7 cells. It also shows potent COX–LOX dual inhibition activity with IC50 values of 15 μM, 0.92 μM and 2.1 μM for COX-1, COX-2 and 5-LOX respectively.

Chemical Structure

Molecular Weight: 954.66

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Quality Control

Batch: E022601 DMSO]100 mg/mL]false]]]false]]]false Purity: 99.88%

Cited in Nature Medicine for its top-tier quality
COA
SDS
Datasheet

99.88

Related Targets	PD-1/PD-L1 CXCR STING AhR Immunology & Inflammation related CD markers Interleukins Anti-infection Antioxidant Histamine Receptor
Other COX Inhibitors	NS-398 (NS398) Paeoniflorin (NSC 178886) Lumiracoxib Xanthohumol Bufexamac Oroxin B Tolfenamic Acid Nimesulide Ginsenoside Rd Indometacin Sodium

Solubility

In vitro
Batch:

DMSO : 100 mg/mL (104.74 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Average weight of animals: g

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
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Chemical Information, Storage & Stability

Molecular Weight	954.66	Formula	C₂₀H₂₈O₄	Storage (From the date of receipt)	3 years -20°C powder
CAS No.	23094-71-5	--		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent

Mechanism of Action

Targets/IC₅₀/Ki	COX-2 0.92 μM 5-LOX 2.1 μM maltase 6.6 μM(Ki) COX-1 15 μM
References	[1] https://pubmed.ncbi.nlm.nih.gov/18256469/ [2] https://pubmed.ncbi.nlm.nih.gov/19351605/ [3] https://pubmed.ncbi.nlm.nih.gov/19481594/

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