Sodium Monensin

Sodium Monensin, isolated from Streptomyces cinnamonensis, is a well-known representative of naturally polyether ionophore antibiotics.

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Sodium Monensin Chemical Structure

Sodium Monensin Chemical Structure
Molecular Weight: 692.85

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Product Description

Biological Activity

Description Sodium Monensin, isolated from Streptomyces cinnamonensis, is a well-known representative of naturally polyether ionophore antibiotics.
LD50
In vitro Monensin sodium salt (Coban), isolated from Streptomyces cinnamonensis, is a well-known representative of naturally polyether ionophore antibiotics. Monensin is an ionophore related to the crown ethers with a preference to form complexes with monovalent cations such as: Li+, Na+, K+, Rb+, Ag+, and TI+. [1] Monensin A is able to transport these cations across lipid membranes of cells, playing an important role as an Na+/H+ antiporter. It blocks intracellular protein transport, and exhibits antibiotic, antimalarial, and other biological activities. [2] The antibacterial properties of monensin and its derivatives are a result of their ability to transport metal cations through cellular and subcellular membranes. [3]
In vivo LD50: Mice 335mg/kg (i.g.) [4]; Rats 36.5mg/kg (i.g.); Chickens 185mg/kg (i.g.). [5]
Features

Protocol(Only for Reference)

1

References

[1] Pinkerton M, et al. J Mol Biol, 1970, 49(3), 533-546.

[2] Mollenhauer HH, et al. Biochim Biophys Acta, 1990, 1031(2), 225-246.

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Chemical Information

Download Sodium Monensin SDF
Molecular Weight (MW) 692.85
Formula

C36H61NaO11

CAS No. 22373-78-0
Storage 3 years -20℃Powder
6 months-80℃in DMSO
Synonyms
Solubility (25°C) * In vitro DMSO <1 mg/mL (<1 mM)
Water <1 mg/mL (<1 mM)
Ethanol 100 mg/mL (144 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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Customer Reviews (1)


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Source Tuberc Respir Dis, 2013, 75(1):9-17. Sodium Monensin purchased from Selleck
Method Microscope imaging
Cell Lines NCI-H1299 cells
Concentrations 50 nM
Incubation Time 48 h
Results Growth inhibition induced by rapamycin or erlotinib is enhanced by combination treatment with monensin in NCI-H1299 cells.

Product Citations (1)

Tech Support & FAQs

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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