Choose Your Country or Region

Taxifolin (Dihydroquercetin)

Name: Taxifolin (Dihydroquercetin)
Brand: Selleck Chemicals
SKU: S2366
Rating: 5 (3 reviews)

Catalog No.S2366 Purity: 99.99%

Taxifolin, type I inhibitor for VEGFR-2 kinase, is a flavonoid in many plants such as Taxus chinensis, Siberian larch, Cedrus deodara and so on.

Taxifolin (Dihydroquercetin) Chemical Structure

CAS: 480-18-2

Selleck's Taxifolin (Dihydroquercetin) has been cited by 3 publications

Purity & Quality Control

Batch: Purity: 99.99%

99.99

Taxifolin (Dihydroquercetin) Related Products

Related Targets	VEGFR1 VEGFR2 VEGFR3	Click to Expand
Related Products	Regorafenib Axitinib Cabozantinib (XL184) Nintedanib Vandetanib Lenvatinib Cabozantinib malate Pazopanib Cediranib (AZD2171) Pazopanib HCl Vatalanib (PTK787) 2HCl Regorafenib (BAY-734506) Monohydrate Tivozanib Bevacizumab (anti-VEGF) Linifanib (ABT-869) Anlotinib (AL3818) dihydrochloride Lenvatinib Mesylate SAR131675 Apatinib Regorafenib Hydrochloride Apatinib (YN968D1) mesylate Ki8751 ZM 323881 HCl Semaxanib (SU5416) Nintedanib Ethanesulfonate Salt SU5402 Cediranib Maleate Motesanib Diphosphate (AMG-706) Brivanib (BMS-540215) Motesanib (AMG-706) ZM 306416 KRN 633 Telatinib Fruquintinib SKLB1002 BAW2881 (NVP-BAW2881) SU14813 SU1498 SU5614 SKLB 610 Brivanib Alaninate (BMS-582664) SU5408 SU5204 Ramucirumab (anti-VEGFR2)	Click to Expand
Related Compound Libraries	Tyrosine Kinase Inhibitor Library PI3K/Akt Inhibitor Library Angiogenesis Related compound Library HIF-1 Signaling Pathway Compound Library FDA-approved Anticancer Drug Library	Click to Expand

Signaling Pathway

VEGFR Signaling Pathway

Choose Selective VEGFR Inhibitors

Biological Activity

Description

Taxifolin, type I inhibitor for VEGFR-2 kinase, is a flavonoid in many plants such as Taxus chinensis, Siberian larch, Cedrus deodara and so on.

Targets

VEGFR2 kinase ^[4]

In vitro
In vitro	Taxifolin is not mutagenic and low toxic compared to Qercetin. ^[1] It acts as a potential chemopreventive agent by regulating genes via an ARE-dependent mechanism. ^[2] Taxifolin has shown to inhibit the ovarian cancer cell growth in a dose-dependent manner. ^[3]

References

[4] Sharad Verma, et al. Journal of Applied Pharmaceutical Science. 2012, 2 (1): 41-46.

+ Expand

Chemical Information & Solubility

Molecular Weight	304.25	Formula	C₁₅H₁₂O₇
CAS No.	480-18-2	SDF	Download Taxifolin (Dihydroquercetin) SDF
Smiles	C1=CC(=C(C=C1C2C(C(=O)C3=C(C=C(C=C3O2)O)O)O)O)O
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 61 mg/mL ( (200.49 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 61 mg/mL

Water : Insoluble

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Dilution Calculator Molecular Weight Calculator

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):