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Ammonium Glycyrrhizinate Dehydrogenase inhibitor

Name: Ammonium Glycyrrhizinate
Brand: Selleck Chemicals
SKU: S2376
Availability: InStock
Rating: 5 (4 reviews)

Cat.No.S2376

Ammonium Glycyrrhizinate (AMGZ, Glycyram, Glycyrrhizin ammonium salt, Glycyrrhizic acid ammonium salt) is a unique product from Licorice root with a very high sweetness. This compound is a direct inhibitor of HMGB1 with anti-inflammatory, anti-tumor, anti-diabetic activities. It inhibits growth and cytopathology of several unrelated DNA and RNA viruses. This chemical also inhibits both hepatic delta 4-5-reductase and 11 beta-hydroxysteroid dehydrogenase.

Chemical Structure

Molecular Weight: 839.96

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Quality Control

Batch: Purity: 99%

Related Targets	HSP Transferase P450 (e.g. CYP17) PDE phosphatase PPAR Vitamin Carbohydrate Metabolism Mitochondrial Metabolism Drug Metabolite
Other Dehydrogenase Inhibitors	Vorasidenib (AG-881) (R)-GNE-140 Glycyrrhizin (NSC 167409) CPI-613 (Devimistat) Gossypol Acetate Emodin AGI-5198 AGI-6780 Sodium Dichloroacetate (DCA) NCT-503

Solubility

In vitro
Batch:

DMSO : 100 mg/mL (119.05 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : 5 mg/mL

Ethanol : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

% Tween 80

% ddH₂O

% DMSO

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	839.96	Formula	C₄₂H₆₂O₁₆.NH₃	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	1407-03-0	Download SDF		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	AMGZ, Glycyram, Glycyrrhizin ammonium salt, Glycyrrhizic acid ammonium salt			Smiles	CC1(C2CCC3(C(C2(CCC1OC4C(C(C(C(O4)C(=O)O)O)O)OC5C(C(C(C(O5)C(=O)O)O)O)O)C)C(=O)C=C6C3(CCC7(C6CC(CC7)(C)C(=O)O)C)C)C)C.N

Mechanism of Action

Targets/IC₅₀/Ki	11-beta-hydroxysteroid dehydrogenases
In vitro	Ammonium glycyrrhizinate (AG) prepared from glycyrrhizin dramatically protects AGS cells from H(2)O(2)-induced damage as measured by the integrity of actin cytoskeleton. This compound also inhibits FeSO(4)-induced reactive oxygen radicals in a dose-dependent manner, suggesting the role for it as a free radical scavenger.
In vivo	Ammonium glycyrrhizinate (28 mg/kg) leads to changes in the activity of some enzymes in the brain, the development of parenchymatous dystrophy of the liver which changed to acidophilic necrosis attended with signs of regeneration in mice and rats model. This compound-loaded nonionic surfactant vesicles (NSVs) decreases edema and nociceptive responses when compared with this compound alone and empty NSVs in mice model. It up-regulates interleukin-10 (IL-10) level and down-regulates the tumor neurosis factor-α (TNF-α) level and inhibits the cyclic adenosine monophosphate-phosphodiesterase (cAMP-PDE) activity in the lung tissue of mice. This compound-loaded non-ionic surfactant vesicles shows no toxicity, good skin tolerability and are able to improve the drug anti-inflammatory activity in mice. It significantly decreases triglyceride, cholesterol, low density lipoprotein (LDL) and very low density lipoprotein (VLDL) levels in rats. This chemical increases high density lipoprotein (HDL) levels increased in rats.
References	[1] https://pubmed.ncbi.nlm.nih.gov/19144869/ [2] https://pubmed.ncbi.nlm.nih.gov/9206575/ [3] https://pubmed.ncbi.nlm.nih.gov/24493924/ [4] https://pubmed.ncbi.nlm.nih.gov/23041542/ [5] https://pubmed.ncbi.nlm.nih.gov/25298583/

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT02939144	Completed	Apparent Mineralocorticoid Excess	The Royal Wolverhampton Hospitals NHS Trust	November 2016	Not Applicable

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