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Cinnamic acid

Name: Cinnamic acid
Brand: Selleck Chemicals
SKU: S3677
Rating: 5 (1 reviews)

Synonyms: trans-Cinnamic acid, Phenylacrylic acid, Cinnamylic acid, 3-Phenylacrylic acid|(E)-Cinnamic acid, Benzenepropenoic acid, Isocinnamic acid

Catalog No.S3677 Purity: 99.98%

Cinnamic acid (Benzenepropenoic acid, Isocinnamic acid, trans-Cinnamic acid, Phenylacrylic acid), a naturally occurring aromatic fatty acid of low toxicity, induces cytostasis and a reversal of malignant properties of human tumor cells in vitro.

Cinnamic acid Chemical Structure

CAS: 140-10-3

Selleck's Cinnamic acid has been cited by 1 publication

Purity & Quality Control

Batch: S367701 DMSO] 29 mg/mL] false] Ethanol] 29 mg/mL] false] Water] Insoluble] false Purity: 99.98%

99.98

Cinnamic acid Related Products

Biological Activity

Description	Cinnamic acid (Benzenepropenoic acid, Isocinnamic acid, trans-Cinnamic acid, Phenylacrylic acid), a naturally occurring aromatic fatty acid of low toxicity, induces cytostasis and a reversal of malignant properties of human tumor cells in vitro.

In vitro
In vitro	Cinnamic acid reduces cell proliferation of glioblastoma, melanoma, prostate and lung carcinoma cells by 50% at concentrations between 1.0 and 4.5 mM. The antiproliferative activity of the drug is associated with caspase 9 activation, but not p53 phosphorylation, after 24 h treatment. Cinnamic acid shows genotoxic potential at both tested concentrations, inducing the formation of micronucleated cells^[1]. Cinnamic acid (tCA) upregulates the expression of acetyl‑H3 and acetyl‑H4 proteins in a dose-dependent manner in treated cells and in the tumor tissue of treated mice. expression of Bcl-2 (a marker of cell proliferation) is reduced, and apoptosis is induced by Cinnamic acid^[2].
Cell Research	Cell lines	HT-144
	Concentrations	0.0125 to 3.2 mM
	Incubation Time	48 h
	Method	Briefly, 1 × 10⁴ cells are seeded in each well containing 100 μL of DMEM plus 10% of FBS in a 96-well plate. After 24 h, various concentrations of cinnamic acid are added. The control group receives rug-free medium. After 2 days, 15 μL of "Dye Solution" are added to each well and the plates were incubated for additional 4 h. Then, 100 μL of “Solubilization/Stop Solution” are added in each well and the optical density is measured at 570 nm

In Vivo
In vivo	In vivo studies indicate that acute lethal doses (LD50) of cinnamic acid is achieved at 160-220 mg/kg (ip) in mice, 2.5 g/kg (oral) in rats and 5 g/kg (dermal) in rabbits. Thus, cinnamic acid exhibits a low toxicity^[1]. Cinnamic acid could suppress the growth of colon carcinoma HT29 xenografts at well-tolerated doses^[2].
Animal Research	Animal Models	BALB/c nude mice
	Dosages	1.0 and 1.5 mmol/kg
	Administration	intragastrically administered

References

Chemical Information & Solubility

Molecular Weight	148.16	Formula	C₉H₈O₂
CAS No.	140-10-3	SDF	Download Cinnamic acid SDF
Smiles	C1=CC=C(C=C1)C=CC(=O)O
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 29 mg/mL ( (195.73 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 29 mg/mL

Water : Insoluble

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Dilution Calculator Molecular Weight Calculator

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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