Home NF-κB NF-κB inhibitor - LTR inhibitor (+)-α-Lipoic acid For research use only.

(+)-α-Lipoic acid

Synonyms: (R)-(+)-α-Lipoic acid, α-Lipoic acid, Alpha-Lipoic acid

(+)-α-Lipoic acid ((R)-(+)-α-Lipoic acid, α-Lipoic acid, Alpha-Lipoic acid), a physiological form of thioctic acid, is a strong antioxidant that relieves diabetic neuropathic symptoms. It shows superior antioxidative effects to its racemate. R(+)-α-lipoic acid is an essential cofactor of mitochondrial enzyme complexes. R(+)-α-lipoic acid inhibits NF-κB-dependent HIV-1 LTR activation.

(+)-α-Lipoic acid Chemical Structure

(+)-α-Lipoic acid Chemical Structure

CAS: 1200-22-2

Purity & Quality Control

Batch: S399801 DMSO] 41 mg/mL] false] ] ] false] ] ] false Purity: 99.78%
99.78

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Biological Activity

Description (+)-α-Lipoic acid ((R)-(+)-α-Lipoic acid, α-Lipoic acid, Alpha-Lipoic acid), a physiological form of thioctic acid, is a strong antioxidant that relieves diabetic neuropathic symptoms. It shows superior antioxidative effects to its racemate. R(+)-α-lipoic acid is an essential cofactor of mitochondrial enzyme complexes. R(+)-α-lipoic acid inhibits NF-κB-dependent HIV-1 LTR activation.
Targets
NF-κB [2] LTR [1] LTR [2]
In vitro
In vitro

Using L6 myotubes and 3T3-L1 adipocytes as a model of muscle and fat cells in culture, R(+)-α-lipoic acid (R-LA) is shown to increase tyrosine phosphorylation of insulin receptor and IRS-1, to enhance PI 3-kinase and Akt1 activities, to elevate GLUT4 content in the plasma membranes, and to increase glucose uptake into the cells. 3T3-L1 adipocytes possess a low capacity to reduce R-α-lipoic acid and the oxidized isoforms are effective in stimulating glucose transport. R-α-lipoic acid modulates glucose transport by changing intracellular redox status. Insulin receptor is a target of R-LA action[1].
Cell Research Cell lines 3T3-L1 preadipocytes
Concentrations 250 μM
Incubation Time 2-48 h
Method

Cells seeded in 12-well plates were incubated for 2–48 h with R-LA (250 μM) and loaded with H2DCF-DA (20 μM) for the last 30 min in PBS containing R-LA. For some experiments cells were washed and incubated with R-LA (0.25-1 μM) and H2DCF-DA (20 μM) for 30 min. Following the treatments, cells were gently scraped by a lifter and suspended in the same media. For detection of intracellular fluorescence, cells were excited using a 488-nm argon-ion laser in a flow cytometer. The dichlorofluorescein (DCF) emission was recorded at 530 nm. Data were collected from at least 20,000 cells.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05808946 Recruiting
Sepsis
Ain Shams University
 March 10 2023 Phase 2|Phase 3
NCT01877590 Completed
Type 2 Diabetes|Coronary Artery Disease|Left Ventricular Mass
Wuhan General Hospital of Guangzhou Military Command
 November 2013 Phase 4
NCT01895699 Completed
Contrast Agent|Endothelial Function|Cytokines|Apoptosis of Endothelial Progenitor Cell|Free Radical|Alpha-lipoic Acid
Xiang Guang-da|Wuhan General Hospital of Guangzhou Military Command
 July 2013 Phase 4
NCT02056366 Completed
Type 2 Diabetes|Cardiac Autonomic Neuropathy
The Catholic University of Korea
 January 2010 Phase 4

Chemical Information & Solubility

Molecular Weight 206.33 Formula

C8H14O2S2
CAS No. 1200-22-2 SDF --
Smiles C1CSSC1CCCCC(=O)O
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 41 mg/mL ( (198.71 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


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