Home Cytoskeletal Signaling PKC activator Decursinol angelate For research use only.

Decursinol angelate

Decursinol angelate is a cytotoxic and protein kinase C activating agent from the root of Angelica gigas.

Decursinol angelate Chemical Structure

Decursinol angelate Chemical Structure

CAS: 130848-06-5

Purity & Quality Control

Batch: S381901 DMSO] 65 mg/mL] false] ] ] false] ] ] false Purity: 99.62%
99.62

Decursinol angelate Related Products

Signaling Pathway

PKC Signaling Pathways

PKC Signaling Pathway

Choose Selective PKC Inhibitors

Biological Activity

Description Decursinol angelate is a cytotoxic and protein kinase C activating agent from the root of Angelica gigas.
Targets
PKC [2]
In vitro
In vitro Decursinol angelate (DA) blocks PGE2-induced activation of the EP2 receptor signaling pathway, including the activation of PKA and the phosphorylation of CREB. Decursinol angelate also inhibits PGE2-induced expression of cyclooxygenase-2 and the activation of the Ras/Raf/Erk pathway, which activates downstream targets for cell survival. Decursinol angelate greatly reduces the PGE2-induced activation of NF-κB p50 and p65 subunits. It has been reported to suppress the growth of estrogen-stimulated and estrogen-independent growth and survival of breast cancer MCF-7 and MDA-MB-231 cells. Decursinol angelate also suppresses the growth of cancer cells through the inhibition of phosphatidylinositol 3'-kinase (PI3K)/Akt, extracellular-signal-regulated kinase (Erk) and nuclear factor-κB (NFκB). Decursinol angelate has anti-leukemic activity through the suppression of protein kinase C activation in human leukemia cells[1].
Cell Research Cell lines MCF-7 cells
Concentrations 10 μM, 20 μM, 50 μM
Incubation Time 24 hours
Method

Cells are treated with decursinol angelate at different exposure concentrations (10 μM, 20 μM, 50 μM) for 24 hours in complete medium.
In Vivo
In vivo Decursinol angelate has anti-angiogenic activity both in vitro and in vivo[1].
Animal Research Animal Models Jugular vein cannulated CD male rats
Dosages 50 mg/kg
Administration oral

Chemical Information & Solubility

Molecular Weight 328.36 Formula

C19H20O5
CAS No. 130848-06-5 SDF Download Decursinol angelate SDF
Smiles CC=C(C)C(=O)OC1CC2=C(C=C3C(=C2)C=CC(=O)O3)OC1(C)C
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 65 mg/mL ( (197.95 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy Decursinol angelate | Decursinol angelate supplier | purchase Decursinol angelate | Decursinol angelate cost | Decursinol angelate manufacturer | order Decursinol angelate | Decursinol angelate distributor