Laetrile

Catalog No.S2260

Laetrile is a glycoside initially isolated from the seeds of the tree Prunus dulcis, also known as bitter almonds.

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In DMSO USD 160 In stock
USD 120 In stock
USD 370 In stock
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Laetrile Chemical Structure

Laetrile Chemical Structure
Molecular Weight: 457.43

Validation & Quality Control

MSDS

Related Compound Libraries

Laetrile is available in the following compound libraries:

Product Information

Product Description

Biological Activity

Amygdalin is a glycoside initially isolated from the seeds of the tree Prunus dulcis, also known as bitter almonds. The metabolism of amygdalin produces hydrogen cyanide, a potent toxin. Beta-glucosidase, one of the enzymes that catalyzes the release of cyanide from amygdalin, is present in human small intestine and in a variety of common foods. This leads to an unpredictable and potentially lethal toxicity when amygdalin or laetrile is taken orally. Ingestion of purified amygdalin or apricot seeds can cause severe toxicity and death due to cyanide poisoning. Numerous case reports in the medical literature describe serious cyanide poisoning in patients who ingested laetrile as a cancer treatment. LD50: Rats 880mg/kg (i.g.).

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesBaboonDogMonkeyRabbitGuinea pigRatHamsterMouse
Weight (kg)121031.80.40.150.080.02
Body Surface Area (m2)0.60.50.240.150.050.0250.020.007
Km factor202012128653
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)

Chemical Information

Download Laetrile SDF
Molecular Weight (MW) 457.43
Formula

C20H27NO11

CAS No. 29883-15-6
Storage 3 years -20℃Powder
6 months-80℃in DMSO
Synonyms Amygdalin
Solubility (25°C) * In vitro DMSO 92 mg/mL (201 mM)
Water <1 mg/mL (<1 mM)
Ethanol 92 mg/mL (201 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Research Area

Tech Support & FAQs

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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