Home NF-κB NF-κB inhibitor - TRP Channel antagonist (E)-Cardamonin For research use only.

(E)-Cardamonin

Synonyms: Alpinetin chalcone, cardamomin

(E)-Cardamonin (Alpinetin chalcone, cardamomin) is a naturally occurring chalcone with strong anti-inflammatory activity. It is a novel TRPA1 antagonist with IC50 of 454 nM and also a NF-κB inhibitor.

(E)-Cardamonin Chemical Structure

(E)-Cardamonin Chemical Structure

CAS: 19309-14-9

Purity & Quality Control

Batch: S386701 DMSO] 87 mg/mL] false] ] ] false] ] ] false Purity: 99.81%
99.81

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Signaling Pathway

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Biological Activity

Description (E)-Cardamonin (Alpinetin chalcone, cardamomin) is a naturally occurring chalcone with strong anti-inflammatory activity. It is a novel TRPA1 antagonist with IC50 of 454 nM and also a NF-κB inhibitor.
Targets
NF-κB [2]
(Cell-free assay)		 TRPA1 [1]
(Cell-free assay)
454 nM
In vitro
In vitro Cardamonin inhibits cancer cell growth by inducing G2/M phase cell cycle arrest and apoptosis via accumulation of ROS. Cardamonin has been reported to have anti-inflammatory and anti-tumor activities. Cardamonin inhibits activation of the NF-κB pathway, which in turn triggers ROS accumulation to activate JNK mitogen-activated protein kinase (MAPK). Cardamonin inhibits viability of NPC cells. It induces G2/M phase arrest in CNE-2 cells. Cardamonin-induced accumulation of ROS is mediated through inhibition of the NF-κB pathway[2]. Cardamonin selectively blocks TRPA1 activation while did not interact with TRPV1 nor TRPV4 channel[1].
Cell Research Cell lines NPC cells
Concentrations 10 μM
Incubation Time 24, 48 and 72 h
Method Cell viability assay: NPC cells are treated with 10 μM cardamonin or 0.1% DMSO, absorbance is measured after 24, 48 and 72 h of treatment.
In Vivo
In vivo Cardamonin inhibits tumor growth in vivo without serious side effects[2].
Animal Research Animal Models Xenograft model (BALB/c nude mice)
Dosages 5 mg/kg
Administration i.p.

Chemical Information & Solubility

Molecular Weight 270.28 Formula

C16H14O4
CAS No. 19309-14-9 SDF --
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 87 mg/mL ( (321.88 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


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