Home Metabolism PPAR inhibitor Propyl gallate For research use only.

Propyl gallate

Synonyms: Gallic acid propyl esterZ, n-Propyl gallate

Propyl gallate (Gallic acid propyl esterZ, n-Propyl gallate) is an antioxidant used in foods especially animal fats and vegetable oils, also in a wide variety of cosmetics and beauty care products.

Propyl gallate Chemical Structure

Propyl gallate Chemical Structure

CAS: 121-79-9

Purity & Quality Control

Batch: S511301 DMSO] 42 mg/mL] false] ] ] false] ] ] false Purity: 99.92%
99.92

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Biological Activity

Description Propyl gallate (Gallic acid propyl esterZ, n-Propyl gallate) is an antioxidant used in foods especially animal fats and vegetable oils, also in a wide variety of cosmetics and beauty care products.
In vitro
In vitro Propyl gallate (PG) could modulate heme oxygenase-1 (HO-1) activation and decrease lung cancer cell survival. Propyl gallate also induces apoptosis in human leukemia cells and HeLa cells by increasing reactive oxygen species (ROS) levels and glutathione (GSH) depletion. Propyl gallate inhibits the expression of MMP-2 and MMP-9 and exerts an antimigration effect on TMZ-treated U87MG cells. Propyl gallate also possesses anti-inflammatory activity via downregulation of the NF-κB pathway. Propyl gallate could reduce the proliferation and augment the chemosensitivity of a THP-1 leukemia cell line via extrinsic and intrinsic apoptotic pathways[1].
Cell Research Cell lines U87MG glioma cells
Concentrations 50 or 100 μM
Incubation Time 48 h
Method U87MG cells (1 × 104) are seeded in each well of a 96-well cultured plate for 24 h and then treated with TMZ (200 μM), PG (50 or 100 μM), or their combination for 48 h. After treatment, cell viability is determined by an XTT-based assay.
In Vivo
In vivo In brain ischemia, Propyl gallate inhibits the activity of NF-κB, reduces COX-2 and TNF-alpha G expression, and decreases ischemic-reperfusion injury[1].

Chemical Information & Solubility

Molecular Weight 212.20 Formula

C10H12O5
CAS No. 121-79-9 SDF Download Propyl gallate SDF
Smiles CCCOC(=O)C1=CC(=C(C(=C1)O)O)O
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 42 mg/mL ( (197.92 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


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In vivo
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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