Oleuropein

Catalog No.S7867

Oleuropein Chemical Structure

Molecular Weight(MW): 540.51

Oleuropein is an antioxidant polyphenol isolated from olive leaf. Phase 2.

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Biological Activity

Description Oleuropein is an antioxidant polyphenol isolated from olive leaf. Phase 2.
In vitro

In both J774A.1 cells and primary mouse macrophages, Oleuropein increases LPS-induced NO production. [1] Oleuropein prevents oxidative myocardial injury induced by ischemia and reperfusion. [2] In TF-1a; 786-O, T-47D, RPMI-7951, LoVo, and NL-Fib cells, Oleuropein inhibits cell proliferation and migration. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
rat IEC-18 cells M1;KbmZ2dmO2aX;uJIF{e2G7 Mn60TY5pcWKrdHnvckBw\iCOUGOtbY5lfWOnZDDwN|ghVUGSSzDwbI9{eGixconsZZRqd25iaX6gdoF1KEmHQz2xPEBk\WyuczDheEAyODBidV2gbY5kfWKjdHXkJIZweiBzIHjyJJBzcW:{IITvJGxRWyClaHHscIVv\2VibXXhd5Vz\WRiYX\0[ZIhOzBibXnud{BjgSCZZYP0[ZJvKGKub4SgZY5idHm|aYO= MVOyN|c2QDFzMB?=

... Click to View More Cell Line Experimental Data

In vivo In swiss albino mice that spontaneously develop soft tissue sarcomas, Oleuropein (i.p. or p.o.) completely regresses tumors. [3] In rats, Oleuropein (40 mg/kg, p.o.) protects from cardiac remodeling process after isoproterenol-induced myocardial infarction through inhibiting angiotensin-converting enzyme activity. [4]

Protocol

Cell Research:

[3]

+ Expand
  • Cell lines: TF-1a; 786-O, T-47D, RPMI-7951, LoVo, and NL-Fib cells
  • Concentrations: --
  • Incubation Time: 5 days
  • Method:

    Approximately 5 × 103 cells (TF-1a; 786-O, T-47D, RPMI-7951, LoVo, and NL-Fib) are seeded in triplicate wells of 96-well plates in 100 μl of their respective growth medium with increasing doses of purified Oleuropein. Cell proliferation is determined on day 5 using the CellTiter MTS cell proliferation kit according to the manufacturer’s instructions. Absorbance at 490 nm is measured with a Bio-Tek Instruments microplate reader. Background readings are subtracted from the experimental readings.


    (Only for Reference)
Animal Research:

[3]

+ Expand
  • Animal Models: Swiss albino mice that spontaneously develops soft tissue sarcomas
  • Formulation: PBS
  • Dosages: 50 μg/mouse
  • Administration: i.p. or p.o.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 100 mg/mL (185.01 mM)
Water 100 mg/mL warmed (185.01 mM)
Ethanol 100 mg/mL warmed (185.01 mM)
In vivo Add solvents individually and in order:
PBS
30mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 540.51
Formula

C25H32O13

CAS No. 32619-42-4
Storage powder
Synonyms N/A

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID