||Brigatinib (AP26113) is a potent and selective ALK (IC50, 0.6 nM) and ROS1 (IC50, 0.9 nM) inhibitor. It also inhibits ROS1, FLT3, and mutant variants of FLT3 (D835Y) and EGFR with lower potentcy.
||Troglitazone is a potent agonist for the peroxisome proliferator-activated receptor-(PPAR) that is a ligand activated transcription factor regulating cell differentiation and growth.
||Tamsulosin is a potent and selective α1a adrenergic receptor antagonist.
||Perphenazine is a phenothiazine derivative and a dopamine antagonist with antiemetic and antipsychotic properties.
||Latanoprost is a prostaglandin F2alpha analogue and a prostanoid selective FP receptor agonist with an ocular hypertensive effect. Latanoprost increases uveoscleral outflow and thereby reduces intraocular pressure.
||Etretinate is an oral aromatic retinoid acid which is effective in psoriasis and other dermatological syndromes. It activates retinoid receptors, causing an induction of cell differentiation, inhibition of cell proliferation, and inhibition of tissue infiltration by inflammatory cells.
||Benzamide, an inhibitor of poly(ADP-ribose) polymerase, is a derivative of benzoic acid.
||Evans Blue is a potent inhibitor of the uptake of L-glutamate into synaptic vesicles, also an AMPA/kainate receptor antagonist.
||Melphalan is a phenylalanine derivative of nitrogen mustard with antineoplastic activity.
||Liraglutide is a long-acting glucagon-like peptide-1(GLP-1) receptor agonist.
||Etonogestrel is a synthetic form of the naturally occurring female sex hormone progesterone. It binds to the cytoplasmic progesterone receptors in the reproductive system and subsequently activates progesterone receptor mediated gene expression.
||Povidone iodine is a stable chemical complex of polyvinylpyrrolidone (povidone, PVP) and elemental iodine. It is used as topical antiseptic in surgery and for skin and mucous membrane infections, also as aerosol.
||Efavirenz is a synthetic non-nucleoside reverse transcriptase (RT) inhibitor with antiviral activity.
||Carbinoxamine maleate is a histamine-H1 receptor blocking agent with antihistamine and anticholinergic properties.
||Perampanel is an orally active, non-competitive, and selective alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) glutamate receptor antagonist, with anti-epileptic activity.
||Procaine is a benzoic acid derivative with local anesthetic and antiarrhythmic properties. Procaine binds to and inhibits voltage-gated sodium channels, thereby inhibiting the ionic flux required for the initiation and conduction of impulses.
||Lidocaine hydrochloride is a local anesthetic and cardiac depressant used as an antiarrhythmia agent.
||Saxagliptin H2O is a selective and reversible DPP4 inhibitor with IC50 of 26 nM.
||Atazanavir is an azapeptide and HIV-protease inhibitor that is used in the treatment of HIV infections and AIDS in combination with other anti-HIV agents.
||Deoxycholic acid is a cytolytic agent. The physiologic effect of deoxycholic acid is by means of decreased cell membrane integrity.