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Neohesperidin Chemical Structure
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Biological Activity
Neohesperidin is an antioxidant agent with an IC50 of 22.31 µg/ml in the 1,1-diphenyl-2-picryldydrazyl (DPPH) radical-scavenging assay.
Neohesperidin (50 mg/kg) significantly inhibited 55.0% of HCl/ethanol-induced gastric lesions, and increased the mucus content. In pylorus ligated rats, neohesperidin (50 mg/kg) significantly decreased the volume of gastric secretion and gastric acid output, and increased the pH. In addition, neohesperidin inhibited the efflux of the P-glycoprotein substrate rhodamine 123 in a concentration-dependent manner. Neohesperidin also inhibits the growth of Caco-2, CEM/ADR5000 and CCRF-CEM leukaemia cells with IC50 of 0.17, 0.17 and 0.12 mM, respectively. Neohesperidin can be isolated from ethyl acetate fractions of C. jambhiri. [1][2]
Chemical Information
| Molecular Weight (WM): | 610.56 |
|---|---|
| Formula: | C28H34O15 |
| CAS No.: | 13241-33-3 |
| Synonyms: |
N/A
|
| Dissolve in (25°C): | DMSO ≥122mg/mL |
| Water <1mg/mL | |
| Ethanol <1mg/mL | |
| Storage: | 2 years-20°CPowder |
| 1 week-4°Cin DMSO | |
| 1 month-80°in DMSO |
Quality Control & MSDS
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