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Neohesperidin ROS chemical

Name: Neohesperidin
Brand: Selleck Chemicals
SKU: S2332
Availability: InStock
Rating: 5 (6 reviews)

Cat.No.S2332

Neohesperidin (NSC 31048), a flavanone glycoside found in citrus fruits, is an antioxidant agent.

Chemical Structure

Molecular Weight: 610.56

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Quality Control

Batch: Purity: 99.63%

99.63

Related Targets	PD-1/PD-L1 CXCR STING AhR Immunology & Inflammation related CD markers Interleukins Anti-infection Antioxidant COX
Other ROS Inhibitors	MitoQ (Mitoquinone) Mesylate Piperlongumine H2DCFDA (DCFH-DA) Gallic acid Idebenone (20R)Ginsenoside Rg3 Pyrogallol Troxerutin Asiaticoside Sarsasapogenin

Solubility

In vitro
Batch:

DMSO : 100 mg/mL (163.78 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : Insoluble

Ethanol : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

% Tween 80

% ddH₂O

% DMSO

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	610.56	Formula	C₂₈H₃₄O₁₅	Storage (From the date of receipt)	3 years -20°C powder (seal)
CAS No.	13241-33-3	Download SDF		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	NSC 31048			Smiles	CC1C(C(C(C(O1)OC2C(C(C(OC2OC3=CC(=C4C(=O)CC(OC4=C3)C5=CC(=C(C=C5)OC)O)O)CO)O)O)O)O)O

Mechanism of Action

In vitro

Neohesperidin, a flavanone glycoside found in citrus fruits, is an antioxidant agent. This compound is an antioxidant agent with an IC50 of 22.31 μg/ml in the 1,1-diphenyl-2-picryldydrazyl (DPPH) radical-scavenging assay. This compound (50 mg/kg) significantly inhibits HCl/ethanol-induced gastric lesions, and increases the mucus content. In pylorus ligated rats, this compound (50 mg/kg) significantly decreases the volume of gastric secretion and gastric acid output, and increases the pH. In addition, this compound inhibits the growth of Caco-2, CEM/ADR5000 and CCRF-CEM leukaemia cells with IC50 of 0.17, 0.17 and 0.12 mM, respectively.

References

[1] https://pubmed.ncbi.nlm.nih.gov/19367677/
[2] https://pubmed.ncbi.nlm.nih.gov/15757656/

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Handling Instructions

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