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96 Well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode

Kinase Inhibitor Library (96 well)

A unique collection of 277 kinase inhibitors

Catalog No. L1200
5 Reviews 11 Product Citations
Size Price Quantity  
Pre-dissolved in DMSO
100μL/well (10mM solution) USD 6800
250μL/well (10mM solution) USD 9800
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Product Description

Description & Advantages / Product Details Kinase Inhibitor Library Contents Kinase Inhibitor Library Composition Customer Reviews Product Citations

Description & Advantages

  • A unique collection of 277 kinase inhibitors for high throughput screening (HTS) and high content screening (HCS)
  • Bioactivity and safety confirmed by preclinical research and clinical trials
  • Some inhibitors have been approved by the FDA
  • Targets kinases such as RTKs, PI3K, Aurora Kinase, CDK, and MEK
  • Most are ATP competitive
  • Structurally diverse, medicinally active, and cell permeable
  • Rich documentation with structure, IC50, and customer reviews
  • NMR and HPLC validated to ensure high purity

Product Details

Formulation: A collection of 277 kinase inhibitors supplied as pre-dissolved DMSO solutions
Container: 96 Well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode
Stability:
2 weeks 4°C in DMSO
3 months -20°C in DMSO
6 months -80°C in DMSO
Shipping: Blue ice
Packaging: Inert gas

Kinase Inhibitor Library Contents

Download the Kinase Inhibitor Library - SDF Download the Kinase Inhibitor Library - XLSX

Kinase Inhibitor Library Composition

Kinase Inhibitor Library Composition

Customer Reviews (5)

AS-605240 Review
Click to enlarge 		Rating
Source Saraswati Sukumar of Johns Hopkins University School of Medicine. AS-605240 purchased from Selleck
Method Western blot
Cell Lines T47D cells
Concentrations
Incubation Time 1 h
Results AS-605240 treatment resulted in a reduction of AKT phosphorylation in T47D cells.
Axitinib and PF2341066(Crizotinib) Reviews
Click to enlarge 		Rating
Source J Biomol Screen , 2011, 16, 141-154. Axitinib purchased from Selleck
Method Western blot, Multiplexing VimPro-Fluc-MDA-MB-231 spheroid viability
Cell Lines MDA-MB-231 cells
Concentrations 0-100 µM
Incubation Time 24 h
Results When Vimpro-Fluc activity is downregulated between 50% and 70%, there is significant downregulation of vimentin protein expression. When Vimpro-Fluc downregulation reaches ≥70%, then downregulation of vimentin protein expression is more pronounced. of the modulators tested-U0126, dasatinib, axitinib, and pF2341066-all downregulated Vimpro-Fluc activity by≥70%, which correlated with a significant down-reglation of vimentin protein expression. Finally, dose-response curves were generated with both U0126 (IC50 = 2.5 µM) and axitinib (IC50 = 0.25 µM), demonstrating that these small molecules modulate Vimpro-Fluc activity in a dose-dependent manner, indicating that their respective target(s) and signaling pathways play a significant role in maintaining vimentin expression and possibly mesenchymal homeostasis (Fig. B).
Axitinib and PF2341066(Crizotinib) Reviews
Click to enlarge 		Rating
Source J Biomol Screen, 2011, 16, 141-154. Axitinib purchased from Selleck
Method Secondary assay
Cell Lines MDA-MB-231 cells
Concentrations 10 µM
Incubation Time
Results U0126, pF2341066, axitinib, and pKC412 caused significant inhibition of the invasive potential of Mda-Mb-231 spheroids. Conversely, dasatinib, a potent inhibitor of vimentin gene expression, did not significantly alter the invasive potential of MDA-MB-231 spheroids.
BIBW2992(Afatinib), Erlotinib(Tarceva), BMS-536924, PD-0325901 and PF02341066(Crizotinib) Reviews
Click to enlarge 		Rating
Source Int J Proteomics, 2011, Article ID 215496. Afatinib (BIBW2992) purchased from Selleck
Method Nikon inverted-phase microscope
Cell Lines lung tumor cell lines
Concentrations 0.1/1 µM
Incubation Time two weeks
Results Reduction of cell colony size formation was observed by the treatment with the irreversible HER1/2 inhibitor BIBW-2992 in H1975 and H1650 cells as seen when these cells were grown in an anchorage-dependent manner.

Click to enlarge 		Rating
Source AACR 2011Dr. Cediranib (AZD2171) purchased from Selleck
Method Cell viability assay
Cell Lines Ba/F3 cells
Concentrations 0-1000 nM
Incubation Time 72 h
Results Cediranib inhibited the survival of Ba/F3 cell lines expressing the recombinant TEL/kinase domain fusion protein for FGFR1-4 in a dose-dependent manner.

Product Citations (11)

  • (PubMed: 22250956)
  • (PubMed: 23667592)
  • (PubMed: 21613408)
  • (PubMed: 21664897)
  • (PubMed: 21536883)
  • (PubMed: 21447712)
  • (PubMed: 21285347)
  • (PubMed: 21148313)
  • (PubMed: 21106726)
  • (PubMed: 21303981)
  • (PubMed: 21403841)

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