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Dihydroartemisinin (DHA) Chemical Structure
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Biological Activity
Dihydroartemisinin (DHA) is a semi-synthetic derivative of artemisinin and isolated from the traditional Chinese herb Artemisia annua. It is the active metabolite of all artemisinin compounds. It is recommended as the first-line anti-malarial drug with low toxicity. DHA has been shown to possess promising anticancer activities and induce cancer cell death through apoptotic pathways. [1] It is also a drug used to treat malaria. The lactone of artemisinin could selectively be reduced with mild hydride-reducing agents, such as sodium borohydride, potassium borohydride, and lithium borohydride to dihydroartemisinin (a lactol) in over 90% yield. [2]
Chemical Information
| Molecular Weight (WM): | 284.35 |
|---|---|
| Formula: | C15H24O5 |
| CAS No.: | 71939-50-9 |
| Synonyms: |
N/A
|
| Dissolve in (25°C): | DMSO ≥57mg/mL |
| Water <1mg/mL | |
| Ethanol ≥14mg/mL | |
| Storage: | 2 years-20°CPowder |
| 1 week-4°Cin DMSO | |
| 1 month-80°in DMSO |
Quality Control & MSDS
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