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Thymol

Name: Thymol
Brand: Selleck Chemicals
SKU: S5157
Rating: 5 (1 reviews)

Synonyms: 2-isopropyl-5-methylphenol, IPMP

Catalog No.S5157 Purity: 99.94%

Thymol (2-isopropyl-5-methylphenol, IPMP), a naturally occurring monocyclic phenolic compound derived from Thymus vulgaris (Lamiaceae), has been reported to exhibit anti-inflammatory property in vivo and vitro.

Thymol Chemical Structure

CAS: 89-83-8

Selleck's Thymol has been cited by 1 publication

Purity & Quality Control

Batch: S515701 DMSO] 30 mg/mL] false] ] ] false] ] ] false Purity: 99.94%

99.94

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Biological Activity

Description	Thymol (2-isopropyl-5-methylphenol, IPMP), a naturally occurring monocyclic phenolic compound derived from Thymus vulgaris (Lamiaceae), has been reported to exhibit anti-inflammatory property in vivo and vitro.

In vitro
In vitro	Thymol inhibits LPS-induced TNF-α, IL-6 and IL-1β production in BALF. Furthermore, thymol significantly reduces the MPO activity, MDA content, lung wet/dry weight ratio and histopathological changes induced by LPS. In addition, thymol inhibits LPS-induced NF-κB signaling pathway and up-regulates the expression of Nrf2 and HO-1^[1].

In Vivo
In vivo	Thymol has been reported to protect mice against high-fat diet (HFD) induced type 2 diabetes. Thymol alleviates LPS-induced lung inflammation in mice^[1].
Animal Research	Animal Models	Male BALB/c mice
	Dosages	20, 40, 80 mg/kg
	Administration	i.p.

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-01-11)
NCT02202304	Withdrawn	Periodontal Disease\|Caries	Rosa Moreno Lopez\|Ivoclar Vivadent AG\|University of Aberdeen	September 10 2017	Phase 4

References

[1] Yao L, et al. Microb Pathog. 2017, 116:8-12.

Chemical Information & Solubility

Molecular Weight	150.22	Formula	C₁₀H₁₄O
CAS No.	89-83-8	SDF	Download Thymol SDF
Smiles	CC1=CC(=C(C=C1)C(C)C)O
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 30 mg/mL ( (199.7 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

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In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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