Research Area
Product Type
United States ( Change Country )
Cryptotanshinone Chemical Structure
NSC 74859 (S3I-201)
S3I-201 (NSC 74859) is a chemical probe inhibitor of Stat3 activity with IC50 of 86 μM.
Tofacitinib citrate (CP-690550)
Tofacitinib citrate also known as CP-690550 is an JAK kinase inhibitor. An IC50 estimated at 0.2 μM for PV patient progenitor cells.
NSC 74859 (S3I-201)
S3I-201 (NSC 74859) is a chemical probe inhibitor of Stat3 activity with IC50 of 86 μM.
INCB018424 (Ruxolitinib)
INCB018424 (Ruxolitinib) is an orally bioavailable JAK inhibitor (IC50 values for JAK1, JAK2 and JAK3 are 3, 5 and 332 nM, respectively).
AZD1480
AZD1480 is a novel potent small JAK2 inhibitor with an IC50 of 0.26 nM.
LY2784544
LY2784544 is a small molecule selective mutant JAK2 kinase inhibitor with an IC50 of 68 nM.
SGI-1776 free base
SGI-1776 free base is a selective Pim family kinase inhibitor with IC50 of 7 ± 1.8, 363 ± 27.6 and 69 ± 9.2 nM for Pim-1, Pim-2, and Pim-3, respectively.
AZ 960
AZ 960 is a novel small molecule JAK2 kinase inhibitor with an IC50 and Ki of 3 mM and 0.45 nM in vitro, respectively.
Cyt387
Cyt387 is an ATP-competitive small molecule JAK1/JAK2 inhibitor with IC50 of 11 and 18 nM for JAK1 and JAK2, respectively.
NVP-BSK805
NVP-BSK805 dihydrochloride is a potent and selective quinoxaline JAK2 inhibitor with IC50 of 0.48, 0.56 and 0.58 nM for JAK2 JH1, FL JAK V617F and FL JAK2 wt, respectively.
Biological Activity
Cryptotanshinone is a major tanshinone isolated from Salvia miltiorrhiza that exhibits multiple activities. It exhibits antitumor activity via inhibition STAT3 activity with an IC50 of 4.6 μM. It displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). It also improves cognitive impairment in Alzheimer’s disease transgenic mice by inhibition of acetylcholinesterase with an IC50 of 4.09 μM and reduction in Aβ peptide generation. [1][2]
References on Cryptotanshinone
- [1] Neuroscience Letters 2009;452: 90–95
- [2] Cancer Res 2009;69:193-202
Product Information
| Molecular Weight (WM): | 296.36 |
|---|---|
| Formula: | C19H20O3 |
| CAS No.: | 35825-57-1 |
| Synonyms: |
N/A
|
| Dissolve in (25°C): | DMSO ≥12mg/mL |
| Water <1mg/mL | |
| Ethanol ≥10mg/mL | |
| Storage: | 2 years-20°CPowder |
| 1 week-4°Cin DMSO | |
| 1 month-80°in DMSO |
Quality Control & MSDS
Research Area
Notes:
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