Research Area
Product Type
United States ( Change Country )
Bilobalide Chemical Structure
[Ala92]-p16 (84-103)
[Ala92]-p16 (84-103) is a CDK inhibitor with IC50 of 1.5μM for cyclin-dependent kinase-4 (cdk4)/cyclin D1
Bax inhibitor peptide,negative control
Bax inhibitor peptide,negative control is a negative control peptide for the Bax inhibitor peptides V5 and P5.
JIP-1(153-163)
JNK and p38 MAPK inhibitor
pp60 c-src (521-533)(phosphorylated)
SRC kinase inhibitor
STF-62247
Targeting VHL-deficient RCC cells, in renal cell carcinoma (RCC) cells that have lost the von Hippel-Lindau (VHL) tumor suppressor activity (IC50 = 625 μM).
BTZ043 racemate
BTZ043 racemate is a decaprenylphosphoryl-b-D-ribose 2’-epimerase inhibitor with MIC of 2.3 and 9.2 nM for M. tuberculosis H37Rv and Mycobacterium smegmatis, respectively.
GSK690693
GSK690693 is a pan-Akt kinase inhibitor,IC50 of Akt 1, 2, and 3 at 2, 13, and 9 nM respectively.
Odanacatib (MK 0822)
cathepsin K inhibitor with an IC50 of 0.2nM.
Malotilate
Malotilate is a liver protein metabolism improved compound.
PA-824
PA-824 is an experimental anti-tuberculosis drug with MIC of less than 1 μg/mL for tuberculosis.
Biological Activity
Bilobalide is a biologically active terpenic trilactone present in Ginkgo biloba. It is a main constituent of the terpenoids found in Ginkgo leaves. It also exists in minor amounts in the roots Bilobalide is important for producing several of the effects of Gingko biloba extracts, and it has neuroprotective effects, as well as inducing the liver enzymes CYP3A1 and 1A2, which may be partially responsible for interactions between gingko and other herbal medicines or pharmaceutical drugs. Bilobalide has recently been found to be an antagonist at the GABAA and GABAA-rho receptors. Of GABAA, it may possibly be selective for the subunits predominantly implicated in cognitive and memory functioning such as α1. [1][2]
Product Information
| Molecular Weight (WM): | 326.30 |
|---|---|
| Formula: | C15H18O8 |
| CAS No.: | 33570-04-6 |
| Synonyms: |
N/A
|
| Dissolve in (25°C): | DMSO ≥65mg/mL |
| Water <1mg/mL | |
| Ethanol ≥65mg/mL | |
| Storage: | 2 years-20°CPowder |
| 1 week-4°Cin DMSO | |
| 1 month-80°in DMSO |
Quality Control & MSDS
Research Area
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